Northern Kentucky led 58-26 at the end of the first half and had their largest lead at 83-33.
Wabash opened the game with the first five points and led 9-2 in the first four minutes. But Northern Kentucky tied it at 12 and later scored 25 straight to lead 38-14 with 7:40 left in the first half.
The Norse had 11 players log at least 10 minutes and none more than 21.
Jack Davidson had 19 points, Tyler Watson added 14 and Connor Rotterman scored 10 for the Little Giants. Wabash is a Division III member.