Ben Simons scored 24 points and Drake handed Iowa State its first loss of the season, beating the visiting Cyclones 74-65 on Tuesday night.
Rayvonte Rice added 18 points for the Bulldogs (2-0), who snapped a two-game losing streak to Iowa State that included a 91-43 defeat in Ames a year ago.
The Cyclones trailed by as much as 10 with 2:27 left, but Chris Babb's 3-pointer a minute later cut the deficit to 66-63.
Simons responded with a floater and a pair of free throws sandwiched around a missed 3 by Babb, pushing the Bulldogs ahead by seven with 22 seconds left.
Royce White had his second straight double-double, compiling 21 points and 14 rebounds, to lead Iowa State (1-1).
Iowa State trailed by single digits to open the second half and it took nearly eight minutes for the Cyclones to grab the lead. Chris Babb's pull-up 3-point shot put Iowa State up 44-43 with 12:26 left, drawing loud cheers from the sizable contingent of Cyclones fans who made the 35-mile trip to Des Moines.
But a game that had lacked flow from both sides suddenly found some, primarily from the Bulldogs.
Rayvonte Rice, who spent considerable time on the bench with three fouls, came back with seven straight points to put the Bulldogs up 56-50. Simons's fourth 3-pointer of the night made it 59-52 with 5:27 left, and Karl Madison's 3-point play and layup put Drake's lead at 64-56 with just 2:43 left.
Babb and Tyrus McGee each added 10 points for the Cyclones, who shot just 36.8 percent from the field.
Both teams got off to rather sloppy starts, displaying rust accumulated during the offseason.
Drake, picked to finish seventh in the 10-team Missouri Valley Conference led by as much as 18-13 early. The Cyclones struggled to find their rhythm on offense and contain Simons, who hit three 3-point shots.
The Bulldogs took a 30-27 lead into the break as Kraidon Woods eluded three Iowa State defenders who failed to box him out and hit a follow-up shot at the buzzer.
Iowa State was coming off an 86-77 win over Lehigh in the opener last weekend, which wasn't nearly as close as the final indicated.
All four Division I transfers the Cyclones are counting on this season; Royce White, Chris Allen, Chris Babb and Anthony Booker; scored in double figures, led by White's 25 points and 11 rebounds in his first college game.
However, even White had his issues. He stepped on the line during a crucial inbounds play with 22 seconds left, relinquishing the ball to Drake.
Iowa State looked nothing like the team that beat Drake by 48 points a year ago.