Cory Higgins scored 15 of his 18 points in the second half as Colorado outgunned Longwood 104-59 on Sunday.
Levi Knutson added 17 points and Alec Burks had 15 for Colorado (7-3), winners of five straight. Six players finished in double figures.
The five-game winning streak is the longest since the 2005-06 campaign. The Buffaloes are 7-0 at home and have won 19 straight nonconference home games.
Antwan Carter led Longwood (3-10) with 16 points. Jeremiah Bowman had 15 for the Lancers, who have lost eight in a row.
Longwood played without guard Durann Neil, who suffered a hamstring injury in Friday's loss at New Mexico.