The clubs' summer additions also bring a new element to this derby, with Zlatan Ibrahimovic, Eric Bailly, Henrikh Mkhitaryan and Paul Pogba all starting for United, while Nolito, John Stones and just-added goalkeeper Claudio Bravo are all starting for City.
It was an already established City player, Kevin De Bruyne, who struck first in the 15th minute to hush the home crowd. Kelechi Iheanacho, starting in place of the suspended Sergio Aguero, flicked on a header from Aleksandar Kolarov's long ball. De Bruyne put it around Daley Blind with an outstretched right foot to put himself in clear on goal, he struck a low, right-footed blast from 18 yards by David de Gea to open the scoring:
De Bruyne had a hand in making it 2-0 in the 36th minute. He whipped a low shot in from the right, and it ricocheted off the right post. Iheanacho, who was onside when De Bruyne fired, had the ball land right at his foot while he was unmarked six yards out, and he simply put the rebound in to double City's lead, with United players all standing around and waiting for the offside flag that was never raised.
Ibrahimovic pulled back a vital goal for United just minutes before halftime to let the hosts claw back into the game. Bravo, with all eyes on him after Joe Hart's departure, came off his line to try to punch or catch a lofted free kick in his box, but all he could do was tap it right to Ibrahimovic. The Swedish striker happily took advantage and scored for the fourth time this Premier League season with an impressive right-footed, first-time volley from 15 yards out.
Bravo was fortunate not to gift United another scoring opportunity in the 56th minute, after his heavy touch in his own box forced him to scramble to recover. He slid, studs up, into an onrushing Wayne Rooney, but referee Mark Clattenburg did not give the penalty despite Manchester United's shouts.
United had another opportunity to equalize in the 71st minute, as halftime substitute Marcus Rashford latched onto a long ball and ran right at Stones. His chance from just inside the box beat Bravo, but it took a deflection off an offside Ibrahimovic, negating the goal.
Minutes later, City had a chance to restore its two-goal edge, with De Bruyne hitting the post again. He made a near-post run to meet Leroy Sane's pass, and his first-time blast hit off the right post and rolled across the goal mouth without trickling in for City's third.