The first Manchester derby of the season is scheduled for November 1 at the Etihad Stadium, with the reverse slated for April 11.
Liverpool start with a home game against Southampton – Ronald Koeman’s first game in charge – while Chelsea, who finished third in 2013-14, travel to Burnley.
The Clarets, who secured promotion back to the top flight under Sean Dyche, then travel to Swansea before facing United at Turf Moor.
Championship-winning Leicester face a challenging start. A home match against Everton is followed by games against Chelsea and Arsenal.
The Gunners start at home to Crystal Palace, while north London rivals Tottenham – managed now by Mauricio Pochettino – face West Ham at Upton Park. The third match in London on the opening weekend of the season sees QPR take on beaten FA Cup finalists Hull.
Alan Irvine’s first Premier League match as West Brom manager is a home contest against Sunderland, who secured Premier League survival thanks to a stirring revival under the leadership of Gus Poyet.
Harry Redknapp’s QPR – promoted after a play-off final win – host Hull on day one. The other match pairs Stoke and Aston Villa at the Britannia Stadium.
There are some appealing Boxing Day fixtures, including two London derbies. Arsenal are at home to QPR, while Chelsea host West Ham.
Elsewhere on December 26, Burnley tackle Liverpool at Turf Moor, Manchester City are at West Brom, while United are at home to Newcastle. Spurs head to Leicester, Sunderland host Hull, Palace take on Southampton, Everton meet Stoke and Villa go to Swansea.
Stoke is Liverpool’s destination on the final week of the season, when City are at home to Southampton and United travel to Hull.
Sunday, May 24 also sees Everton take on Tottenham, while Leicester and QPR are set to meet in a game which could be significant at the bottom end of the table. Arsenal wrap up against West Brom, Burnley go to Villa, Chelsea meet Sunderland, Palace meet Swansea and Newcastle take on West Ham.