Nacional and Defensor Sporting remain in contention for their first Copa Libertadores title after both advanced to the quarter-finals.
Paraguayan side Nacional reached the last eight for the first time in their history after a a 2-2 draw with Velez Sarsfield in Argentina secured a 3-2 aggregate win.
All the goals came in the final 15 minutes as 1994 champions Velez finally broke the deadlock through Jorge Correa – but their lead lasted only four minutes.
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Lucas Romero’s foul on Derlis Orue earned the Velez midfielder a red card and gave Silvio Torales the chance to equalise from the spot.
Correa scored again in the 84th minute but Orue struck from a counter-attack in injury time to leave Nacional celebrating, as they await a tie against Arsenal of Argentina or Chile’s Union Espanola.
Nacional goalkeeper Ignacio Don told Fox Sports: "I thank my team-mates for such a big effort. We have made history against a great team and we are tremendously happy for that."
Defensor eliminated Bolivia’s The Strongest on penalties.
Giorgian De Arrascaeta and Nicolas Olivera claimed second-half goals as the Uruguayan side claimed a 2-0 home win before winning the shoot-out 4-2, Martin Campana saving from Ernesto Cristaldo and Marcos Barrera.
Defensor will face reigning champions Atletico Mineiro of Brazil or Colombian giants Atletico Nacional, and attacking midfielder Adrian Luna told El Observador newspaper: "We have what it takes to achieve great things. Match by match we are closer to our dream."