United confirmed the news on their website this morning.
"The decision to retire is one that I have thought a great deal about and one that I have not taken lightly,” said Ferguson. "It is the right time."
Ferguson’s last game in charge will be at West Brom on May 19 and he will join the club’s football board. "It was important to me to leave an organisation in the strongest possible shape and I believe I have done so," he said.
"The quality of this league winning squad, and the balance of ages within it, bodes well for continued success at the highest level whilst the structure of the youth set-up will ensure that the long-term future of the club remains a bright one."
Ferguson has had a career the like of which will never be seen again. He won his 49th trophy in United’s 20th league championship and seemed set to extend his career into next season, confirming as much in his program notes ahead of Sunday’s encounter with Chelsea.
Instead, with a hip operation booked in for August, this weekend’s Old Trafford encounter with Swansea, that will be followed by a trophy presentation, will be his last home game in charge.
He leaves behind a club in good shape. "Our training facilities are amongst the finest in global sport and our home Old Trafford is rightfully regarded as one of the leading venues in the world," said Ferguson.
"Going forward, I am delighted to take on the roles of both Director and Ambassador for the club. With these activities, along with my many other interests, I am looking forward to the future. I must pay tribute to my family, their love and support has been essential.
"My wife Cathy has been the key figure throughout my career, providing a bedrock of both stability and encouragement. Words are not enough to express what this has meant to me. As for my players and staff, past and present, I would like to thank them all for a staggering level of professional conduct and dedication that has helped to deliver so many memorable triumphs. Without their contribution the history of this great club would not be as rich."
Although there have been times – in 1989 when it seemed he was going to be sacked, and 2002, when he was about to retire and instead performed a last-minute U-turn – when it was felt Ferguson was ready to leave, this time it is permanent.
The speculation intensified Tuesday afternoon and United’s failure to respond to questioning about the matter further fueled the rumors overnight.
Now, Ferguson is left to look back on the power-shift in English football that he has instigated.
"In my early years, the backing of the board, and Sir Bobby Charlton in particular, gave me the confidence and time to build a football club, rather than just a football team," said Ferguson. "Over the past decade, the Glazer family have provided me with the platform to manage Manchester United to the best of my ability and I have been extremely fortunate to have worked with a talented and trustworthy chief executive in David Gill.
"I am truly grateful to all of them. To the fans, thank you. The support you have provided over the years has been truly humbling. It has been an honor and an enormous privilege to have had the opportunity to lead your club and I have treasured my time as manager of Manchester United."
Now, for the first time in over a quarter of a century, United are on the hunt for a new manager.
David Moyes, out of contract at Everton, and Jose Mourinho, who is expected to leave Real Madrid at the end of the season, are the obvious favorites, although Borussia Dortmund’s highly-regarded coach Jürgen Klopp and Bayern Munich’s 67-year-old outgoing boss Jupp Heynckes will also come into contention.
It promises to be a major test of nerve for the Glazer family, plus Ed Woodward, who will replace David Gill as chief executive in the summer.
"Alex has proven time and time again what a fantastic manager he is but he’s also a wonderful person," said co-chairman Joel Glazer. His determination to succeed and dedication to the club have been truly remarkable.
"I will always cherish the wonderful memories he has given us, like that magical night in Moscow." Avi Glazer added: "I am delighted to announce that Alex has agreed to stay with the Club as a director.
"His contributions to Manchester United over the last 26 years have been extraordinary and, like all United fans, I want him to be a part of its future."
Ferguson’s exit coincides with that of Gill, who hopes to be voted onto UEFA’s executive committee in the summer. "I’ve had the tremendous pleasure of working very closely with Alex for 16 unforgettable years – through the Treble, the double, countless trophy wins and numerous signings," said Gill.
"We knew that his retirement would come one day and we both have been planning for it by ensuring the quality of the squad and club structures are in first class condition. Alex’s vision, energy and ability have built teams – both on and off the pitch – that his successor can count on as among the best and most loyal in world sport.
"The way he cares for this club, his staff and for the football family in general is something that I admire. It is a side to him that is often hidden from public view but it is something that I have been privileged to witness in the last 16 years.
"What he has done for this club and for the game in general will never be forgotten. It has been the greatest experience of my working life being alongside Alex and a great honour to be able to call him a friend."