Despaigne back on the mound Thursday night for Padres

San Diego Padres starting pitcher Odrisamer Despaigne works against the Arizona Diamondbacks in the first inning of a baseball game Tuesday April 14, 2015 in San Diego.

The San Diego Padres and Arizona Diamondbacks were struggling to score before finally breaking out prior to the opener of this four-game series.

Odrisamer Despaigne shut down Arizona last month and he’ll be matched up Thursday night against Rubby De La Rosa, who pitched the Diamondbacks to their only win in that three-game set.

San Diego (15-14) was shut out in its first two games at San Francisco and was on a 22-inning scoreless streak before getting five runs in the third of Wednesday’s 9-1 victory.

Prized prospect Austin Hedges hit an RBI single in the third for his first major league hit and added a sacrifice fly in the eighth in his first start at catcher after being called up from Triple-A El Paso on Monday.

"I thought he handled himself great," manager Bud Black told MLB’s official website. "I had a good sense for today early this morning when Austin was in the clubhouse. He had a good look in the eye."

Wil Myers, Cory Spangenberg and Alexi Amarista each had three hits as the Padres totaled 16 after having six in the first two of the series.

"We were due," Black said. "We think we’re going to hit and we hit. Our guys came in with an edge."

The Diamondbacks (12-14) finally got to play Wednesday after the first two games of their series in Colorado were rained out. They matched a season best with 18 hits while setting a season high for runs in a 13-7 win in the first game of a doubleheader and completed the sweep with a 5-1 victory.

Arizona was shut out twice by the Los Angeles Dodgers in a three-game sweep last weekend.

Aaron Hill went 4 for 5 and tied a career high with four RBIs, Ender Inciarte was 4 for 6 with two RBIs, and Mark Trumbo and Yasmany Tomas drove in three runs apiece in the first game.

Hill added two more hits in the nightcap and Paul Goldschmidt hit his seventh homer and had two RBIs.

"I think it’s going to be less roller coaster-like," said catcher Tuffy Gosewisch, who went 3 for 4 in Game 2. "We have to continue to work hard and do this day in and day out."

Despaigne (2-0, 2.95 ERA) is back in the rotation for the second time after the Padres placed Brandon Morrow on the 15-day disabled list Tuesday. The right-hander won both of his starts in April, including 5-1 over the Diamondbacks after allowing one run and two hits in seven innings.

He’s 0-2 with a 5.06 ERA in two starts at Arizona compared to a 2-0 record and 1.31 ERA in three matchups at home.

De La Rosa (2-2, 5.40) has dropped back-to-back decisions since winning 8-4 at San Diego on April 13 after allowing three runs over six innings.

The right-hander is coming off a rough outing, giving up five runs in the second inning on a grand slam and solo shot and lasting five in an 8-0 loss to the Dodgers on Friday.

"That’s part of the learning process for him," manager Chip Hale said. "He’s had a hard time with those types of innings that have gotten away from him."

Myers is 4 for 7 with two doubles when facing De La Rosa.