Bills RB McCoy unlikely to play, WR Watkins uncertain vs. Giants

Wide receiver Sammy Watkins' status is up in the air for the Buffalo Bills.

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ORCHARD PARK, N.Y. — The Buffalo Bills could be without two playmaking threats against the New York Giants next Sunday.

Running back LeSean McCoy is unlikely to play due to a hamstring injury, FOX Sports 1 NFL insider Mike Garafolo reports. McCoy first sustained the injury during the preseason.

Wide receiver Sammy Watkins’ status is uncertain because of a calf injury.

Coach Rex Ryan provided an update on Monday, a day after Watkins left in the second quarter of the Bills’ 41-14 win at Miami.

Ryan said "it’s a possibility" Watkins won’t be available this week. Bills players had Monday off.

Watkins, the second-year receiver, has seven receptions for 99 yards and a touchdown through the first three games.

The Bills (2-1) host the Giants (1-2) on Sunday.