LeSean McCoy knocked out of Bills’ practice with hamstring injury

LeSean McCoy left practice with a hamstring injury Wednesday and his status for Sunday’s game at Miami is unclear.

Coach Rex Ryan said that McCoy was being evaluated by trainers. He didn’t have any details about how McCoy was hurt and didn’t know the severity of the injury.

"We feel good about the guys that we do have, but that’s assuming he won’t play," Ryan said, when asked how McCoy’s possible absence would affect the game plan. "We’ll see how it goes."

The Buffalo Bills running back is second in the NFL in rushing with 587 yards and coming off a 140-yard, three-TD performance in a win over the 49ers.

McCoy has played a key role in sparking Buffalo’s four-game winning streak — the team’s longest in eight years. It’s a stretch in which he’s combined for 470 yards rushing and six touchdowns, including one receiving.

McCoy is in his second season in Buffalo after the Bills acquired the NFL’s 2013 rushing leader in a trade with Philadelphia. McCoy’s production was slowed last year, when he opened the season with a partially torn left hamstring. He then missed the final two games of the season because of a knee injury.

Mike Gillislee is McCoy’s backup followed by veteran free-agent addition Reggie Bush and rookie fifth-round pick Jonathan Williams.

The Bills offense could also be missing starting receiver Robert Woods, who aggravated an injury to his right foot against San Francisco. Woods was still wearing a protective boot on Wednesday. Starting tight end Charles Clay also didn’t practice after he hurt his ankle on Sunday.

Buffalo is already playing without top receiver, Sammy Watkins, who aggravated an injury to his surgically repaired left foot last month. Watkins was placed on injured reserve and is not eligible to be activated for four weeks.

The Associated Press contributed to this report.