Red Sox beat Padres 7-2 to take over 1st in AL East

Boston Red Sox designated hitter David Ortiz, center, greets relief pitcher Craig Kimbrel (46) after the Red Sox defeated the San Diego Padres 7-2 in a baseball game Wednesday, Sept. 7, 2016, in San Diego. (AP Photo/Gregory Bull)

SAN DIEGO (AP) Travis Shaw, Hanley Ramirez and Brock Holt homered and David Price threw seven solid innings to lead Boston past the San Diego Padres 7-2 on Wednesday night, moving the Red Sox into first place in the AL East.

Shaw, inserted into the lineup for a slumping Yoan Moncada, hit his 16th homer in the second inning, a two-run shot, and added an RBI single in the fourth.

Ramirez's homer came in the eighth off Jake Smith's first major league pitch.

Holt added a pinch-hit homer in the ninth

The Red Sox took a one-game lead over the Toronto Blue Jays, who lost 2-0 to the New York Yankees. Boston, which completed interleague play with a 14-6 record, opens a three-game series in Toronto on Friday.

Price (15-8) won his season-high sixth straight start, allowing two runs and six hits.