"He’s been swinging the bat well for a few days now. It seems like he’s kind of caught fire," manager Don Mattingly said.
Starting in a day game after A.J. Ellis caught the previous night, Grandal went 4 for 4 with two singles and two walks.
Grandal’s previous career high for RBIs was five, done last Sept. 25 when he homered twice against San Francisco.
Alex Guerrero also homered for the Dodgers, his sixth.
Milwaukee, with the worst record in the majors, split a four-game series with the NL West leaders after Craig Counsell replaced fired manager Ron Roenicke.
Carlos Frias (3-0) won for the second time in as many starts. He gave up three runs and six hits in five innings, striking out six and walking one.
"I was able to control both sides of the plate," he said.
When asked if his two starts should earn him a regular spot in the Dodgers rotation, Frias said: "I just get ready to do anything they tell me to do to help the team win. My goal is to stay here."
Mike Fiers (1-4) was lifted in the sixth after walking Guerrero and giving up a triple to Andre Ethier. Fiers allowed five runs on five hits and five walks, and fanned eight.
Adam Lind hit a solo home run and an RBI single for the Brewers. Adrian Gonzalez blooped a two-run single for the Dodgers.
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The Brewers have surrendered a major league-high 42 home runs this season. The Dodgers connected for nine in this series, three by Joc Pederson.
Grandal said players around the league view Miller Park as a home run haven, but not him.
"For me, I’ve never really hit well here. I hit two home runs here today and I don’t really know how. I’ve never really driven the ball here. I’d much rather be playing somewhere else."
Dodgers: Los Angeles optioned P Joe Wieland to Triple-A Oklahoma City, one day after he was called up, and recalled OF Chris Heisey. Wieland started and took the loss in Wednesday night’s game, giving up six runs in 4 2-3 innings. … OF Yasiel Puig, on the 15-day DL with a hamstring injury, was expected to be the DH for Single-A Rancho Cucamonga on Thursday. Mattingly said Puig could possibly play in the outfield on his rehab assignment by Saturday.
Brewers: OF Carlos Gomez was out of the lineup. Milwaukee reinstated Gomez, who injured his right hamstring, from the 15-day DL Saturday. "He’s played five games since, and I think it’s important that we make sure that everything’s OK with him," Counsell said. "He’s been going hard and he’s a little sore."