Betts went 4 for 4, scoring five runs and driving in four. His third career slam capped a nine-run burst in the sixth inning that turned the first matchup of the season between the AL East rivals into a rout.
Sale (1-0) allowed one run in six innings, striking out eight. Luis Severino (2-1) gave up five runs in five innings.
Aaron Judge had three hits for the Yankees, including his third home run of the season.
Yankees slugger Giancarlo Stanton went 2 for 4. He struck out his first two times up against Sale, and has now fanned 22 times in 46 at-bats.
SAN FRANCISCO (AP) – Andrew McCutchen hit a bases-loaded single for his second walk-off of San Francisco’s homestand.
McCutchen lined the first pitch he got from Jorge De La Rosa (0-1) for a clean single into left-center, his 10th career game-ending hit. His previous walk-off was just last Saturday, when he hit a three-run homer to sink the Los Angeles Dodgers in the 14th inning.
BALTIMORE (AP) – Aaron Sanchez lost his no-hit bid when Baltimore’s Tim Beckham led off the eighth inning with a sharp grounder through the legs of third baseman Josh Donaldson, and Curtis Granderson hit a tiebreaking homer in the ninth to carry Toronto.
Seeking to throw the second no-hitter in Blue Jays history – Dave Stieb did it in 1990 – Sanchez (1-1) gave up three hits in the eighth.
Granderson hit his first homer for the Blue Jays, connecting off Darren O’Day (0-1).
Roberto Osuna closed for his fifth save. He became the youngest player in major league history (23 years, 62 days) with 100 career saves.
MIAMI (AP) – Yoenis Cespedes snapped a slump with a two-run double to break a tie in the ninth inning, giving New York the best 10-game start in franchise history.
The Mets (9-1) earned their seventh consecutive victory, their longest winning streak in two years. Asdrubal Cabrera hit a pair of solo homers for New York, which blew a three-run lead and then came from behind.
For the second night in a row, the teams drew the smallest crowd in the seven-season history of Marlins Park. Attendance was 6,516.
ST. LOUIS (AP) – Matt Carpenter hit a two-run home run with no outs in the 11th inning to lift St. Louis.
Carpenter turned around a pitch from J.J. Hoover (0-1) for the third game-ending homer of his career. It capped a night in which St. Louis rallied from one-run deficits in the ninth and 10th innings.
Domingo Santana singled in Eric Thames to put Milwaukee ahead 2-1 in the ninth inning, but Tommy Pham scored from second on a pair of wild pitches by Jacob Barnes to tie it in the bottom of the inning.
After Orlando Arcia singled in a run in the top of the 10th, Greg Garcia made it 3-3 with his own RBI single a half-inning later.
Not even the presence of Sister Jean Dolores Schmidt, the 98-year-old chaplain of the Loyola basketball team, could help the Cubs. She threw out a ceremonial first pitch at Wrigley Field.
Corey Dickerson had three hits and two RBIs and Starling Marte also connected as Pittsburgh won for the fourth time in five games. The Pirates‘ 8-2 record is their best 10-game start since 1992.
Felipe Vazquez got four outs for his first save in a new jersey after he legally changed his surname to match that of his sister, Prescilla. He was known as Felipe Rivero, and he apologized on Twitter on Monday to fans who bought gear with his old name.
Javier Baez homered twice for the Cubs, and Willson Contreras collected three hits. Tyler Chatwood (0-2) was tagged for five runs and nine hits in five innings in his first home start since signing a $38 million, three-year contract with Chicago in the offseason.
LOS ANGELES (AP) – Hyun-Jin Ryu cruised through six innings of one-hit ball and Corey Seager hit one of three Dodgers homers.
Ryu (1-0) rebounded from a rocky season debut to shut down Oakland. He struck out eight and walked one, handing off to the bullpen after just 90 pitches. Ryu also walked and singled in two plate appearances.
Chris Taylor and Seager hit back-to-back homers off Sean Manaea (1-2) in the first inning, and Matt Kemp later added his first homer since returning to Los Angeles in a December trade with Atlanta.
Angels rookie two-way sensation Shohei Ohtani grounded out as a pinch-hitter in the ninth after not playing in the series opener Monday night. Ohtani will DH in the series finale Wednesday.
Trout’s fourth home of the season was a 441-foot solo drive that hit high above the Angels bullpen in left-center in the second inning. Simmons led off the next inning with his first homer to make it 5-1 against Martin Perez (1-1).
Tyler Skaggs (2-0) struck out seven while allowing one run and throwing 114 pitches in five innings. The lefty allowed five hits and walked four.
Nola (1-0) gave up three hits while striking out six and walking three as Philadelphia won for the fourth time in five games. The Reds have lost three in a row.
Kingery connected with one out in the eighth off Tanner Rainey, who was making his big league debut. It was the second career homer for Kingery – he helped the Phillies beat the Reds 6-5 on Monday night by going deep.
MINNEAPOLIS (AP) – Jake Odorizzi grinded through six innings for his first win with Minnesota, and leadoff man Brian Dozier walked a career-high four times.
Odorizzi (1-0) struggled with control on another cold night in Minnesota but eventually settled in during his first home start since being acquired from Tampa Bay in February. He allowed a run on five walks and five hits.
Minnesota took advantage of Dallas Keuchel’s control problems to scratch across three runs in the first two innings. Keuchel (0-2) gave up three runs, five hits and four walks in four innings. He struck out six and left after 101 pitches.
Hernandez (2-1), who was shelled his last time out in San Francisco, allowed three runs, six hits and a walk in 5 2/3 innings. His only big mistake came in the fourth, when Mike Moustakas turned on a 2-1 pitch and sent a two-run homer screaming into the right-field fountains.
Eric Skoglund (0-1) was hardly as efficient or effective. The lanky left-hander allowed five runs, six hits and two walks in 4 2/3 innings.