The 44-year-old Colon was working on a perfect game for the Texas Rangers before walking Carlos Correa on a 3-1 pitch to start the eighth. Reddick then lined an 0-2 delivery down the right-field line, putting runners at second and third.
Opposing fans in Houston gave Colon a standing ovation, and he clapped his bare hand softly against the outside of his glove.
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Two outs later, Colon was removed with the score tied at 1. He struck out seven and ended up with a no-decision.
On his way from the mound to the dugout, the good-humored Colon gestured toward Reddick with a quick flick of his hand.
Colon threw 96 pitches, 66 for strikes. A fan favorite all around the majors, the beefy right-hander nicknamed ”Big Sexy” is on his ninth team in his last 11 seasons.
Colon’s longest no-hit bid came with the Cleveland Indians on Sept. 18, 2000, when he held the New York Yankees hitless for 7 1/3 innings. He finished with a one-hitter in a 2-0 win at Yankee Stadium.