MESA, Ariz. (AP) The Cubs' Jake Arrieta struck out five batters in four innings of work and left with the game tied 1-1 before the Padres got to Chicago's bullpen for a 10-2 win Monday.
The reigning Cy Young winner had a solid second outing, allowing two hits, one earned run and two walks.
San Diego starter Colin Rea also went four innings, giving up one hit, one earned run and three walks.
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Third baseman Kris Bryant got the Cubs on the board in the first inning with a double off the outfield wall, scoring Ben Zobrist.
The Padres answered in the third when Jemile Weeks singled, stole second and scored on Jon Jay's ground-rule double. They broke it open in the fifth as Jabari Blash and Alexei Ramirez both hit two-run homers off of Pierce Johnson.