It's starting to look like Jordy Mercer will be the everyday shortstop, so what will the Pirates do with Jung-ho Kang? It's hard to imagine he won't play all season, so how will Clint Hurdle work him in?
Getty ImagesChung Sung-Jun
Will Nelson shine?
Jimmy Nelson was dominant in the minor leagues last year but struggled a bit once he was called up to the majors. Now that Nelson has some major-league experience and a spot in the rotation, how will he fare? Did Nelson learn from last year? If so, can he turn that experience into a breakout season in 2015?
Will Votto stay healthy?
If the Reds are going to get back to the playoffs this season, they need a healthy and productive Joey Votto. The 2014 season was a rough one for the Reds' health, but they're starting the new season fresh. Now they just need to stay that way.
Can Lester lead the Cubs to October?
The Cubs had a fascinating of season with plenty of acquisitions, none bigger than Jon Lester. If they're going to have the type of season people are predicting, then Lester is going to have to prove he's worth the amount of money he's making.
Joe Camporeale-USA TODAY SportsJoe Camporeale
Adam Wainwright is the Cardinal's ace, but the team needs to make sure he's out there every fifth day. After injuries popped up toward the end of 2014 and then again at the beginning of camp, questions have surfaced about Wainwright's durability. Mike Matheny needs to manage Wainwright's workload so that he's healthy all year long.