Two days after Reed broke the gavel during the ceremonial closing bell at the New York Stock Exchange, the American kept a clean card and shot 5-under 66 to share the early lead with Martin Laird at The Barclays.
Laird also played bogey-free at Bethpage Black.
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They had a one-shot lead over Emiliano Grillo and a pair of Ryder Cup hopefuls, Rickie Fowler and Kevin Chappell. Defending champion Jason Day, the No. 1 player in the world, shot a 68.
Reed hasn't won this year and is No. 8 in the Ryder Cup standings. This is the final week for Americans to earn the eighth automatic spots on the team. Reed is playing for the third straight week, starting with the Olympics.