Wade, who joined James in being named an Eastern Conference starter, missed his fourth straight game to rest his knees.
Greg Oden, who made his home debut in Tuesday night’s win against Boston, played in both halves. He finished with five points, five rebounds and a block in 10 minutes, 26 seconds.
Pau Gasol and Jodie Meeks each scored a 22 points for the Lakers (16-27).
The Lakers scored the first five points of the fourth quarter against Miami’s second unit to pull within 85-80 with 9:46 remaining. Bosh re-entered after a timeout, and immediately sank a jumper to open up a seven-point cushion.
Bosh had 13 points and James added 11 point and eight rebounds to help Miami build a 57-46 halftime lead.
The Heat shot 56.8 percent (25 of 44), outscored L.A. in the paint 38-18 and won he first-half boards battle 28-19.
Heat newcomer Toney Douglas joined Wade as Miami’s inactives.
THE TURNING POINT
Give the Lakers credit — they fought back to put a scare in the Heat. But Bosh’s jumper with 54.4 seconds remaining gave Miami a 108-101 advantage. After Kendall Marshall missed a 3-point try, James sank 1 of 2 free throws to create an eight-point cushion with 22.8 showing.
THE DIFFERENCE MAKER
Bosh. Not only was he the game’s high scorer, he scored 10 points in the final period. Twice he sank jumpers after L.A. had gotten within five points.
STAT OF THE GAME
Rebounding hasn’t been the Heat’s strongsuit this season, yet Miami outrebounded L.A. 48-35.
The Heat will play the third of a four-game homestead on Sunday against the San Antonio Spurs at 1 p.m.