No. 2 Clemson plays first game with Georgia Southern

Georgia Southern (2-0) at No. 2 Clemson (2-0), 3:30 p.m. (ESPN2)

Line: Clemson by 33½.

Series Record: First meeting.

WHAT’S AT STAKE?

Georgia Southern will be looking for its first road nonconference win — along with one of the biggest upsets in program history — since joining the Football Bowl Subdivision in 2014. Clemson is seeking a crisp game in its last contest before starting Atlantic Coast Conference play.

KEY MATCHUP

Georgia Southern QB Shai Werts vs. Clemson’s defense: Werts has accounted for six touchdowns in the Eagles 2-0 start, tying the Eagles number of wins from all of last year. He’ll have his hands full with a Clemson front four that knocked Texas A&M passer Kellen Mond down 18 times last week.

PLAYERS TO WATCH

Georgia Southern: RB Wesley Fields has had a strong start in the Eagles’ option attack this season, gaining 173 yards and a touchdown in 33 carries.

Clemson: WR Tee Higgins is a sophomore who leads the Tigers with 158 receiving yards and a per-catch average of 26.3 yards. His catch and run against Texas A&M made most weekend highlight packages.

FACTS AND FIGURES

Clemson enters as one of only five FBS teams with zero turnovers. Georgia Southern has just one. … Georgia Southern is fourth in FBS rushing so far, gaining 326 yards per game. … The Eagles have lost their past 11 nonconference road games since upsetting Florida at The Swamp 26-20 in 2013. … Clemson has won its past 15 games in September since falling at Florida State 23-17 in 2014. … Clemson has three players within 150 yards of gaining 1,000 rushing yards for their careers in QB Kelly Bryant (941) and tailbacks Tavien Feaster (913) and Travis Etienne (873). … Werts is from South Carolina and is related to Chicago Cubs pitcher Carl Edwards Jr.