Willie Reed scored 15 points and had 12 rebounds and Brian Conklin had 15 points to lead Saint Louis to a 59-41 victory over Southeast Missouri State on Saturday night.
Kwamain Mitchell added 13 points for the Billikens (1-0), who helped coach Rick Majerus improve to 22-1 in season openers.
Anthony Allison and Derek Thompson had 10 points to lead Southeast Missouri State (0-1), which was playing its first game under new coach Dickey Nutt.
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Saint Louis scored the first six points of the second half for a 36-20 lead. Southeast Missouri State followed with a 16-5 run, including six points from Allison and four from Thompson, to pull within 41-36 with 10 minutes left.
The Billikens put the game away with a 8-0 run. Kyle Cassity had a 3-pointer, and Reed added a dunk and free throw to put Saint Louis ahead 49-36 with 5:21 left.