Twins vs. Guardians Prediction, Odds, Picks - September 19

Trevor Larnach and Steven Kwan will be among the stars on display when the Minnesota Twins face the Cleveland Guardians on Friday at 8:10 p.m. ET, at Target Field. The Twins are -110 moneyline favorites in this matchup with the Guardians (-109). Cleveland is the run-line favorite (-1.5). The total for the contest has been listed at 8 runs.

Take a look at everything you need to know from a betting perspective on the Twins-Guardians game, regarding the run line, moneyline and total, plus expert picks.

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Twins vs. Guardians Game Information & Odds

• When: Friday, September 19, 2025 at 8:10 p.m. ET
• Where: Target Field in Minneapolis, Minnesota
• How to watch on TV: MNNT and CLEG

Twins vs. Guardians Prediction

• Score Prediction: Twins 5, Guardians 4
• Total Prediction: Under 8 runs
• Win Probabilities: Twins 50%, Guardians 50%

Twins vs. Guardians Betting Insights

• This season, the Twins have been favored 86 times and won 39, or 45.3%, of those games.
• Minnesota is 41-48 this season when entering a game favored by -110 or more on the moneyline.
• The moneyline for this contest implies a 52.4% chance of a victory for the Twins.
• The Guardians have been chosen as underdogs in 85 games this year and have walked away with the win 40 times (47.1%) in those games.
• This season, Cleveland has been victorious 40 times in 85 chances when named as an underdog of at least -109 or worse on the moneyline.
• The Guardians have an implied victory probability of 52.2% according to the moneyline set by oddsmakers for this matchup.

Twins Recent Betting Performance

• The Twins went 1-3 across the four games they were favored on the moneyline in their last 10 matchups.
• Over their last 10 outings, the Twins and their opponents combined to hit the over six times (all 10 of the games had set totals).
• The Twins have a 5-5-0 record against the spread over their past 10 games.

Twins Recent Stats

Twins Player Insights

• Byron Buxton's 31 homers and 76 RBI both lead the Twins, in addition to his team-high .270 average.
• In all of MLB, Buxton ranks 14th in home runs and 53rd in RBI.
• Buxton has collected a hit in three games in a row. During his last five outings he is batting .182 with two doubles and two walks.
• Larnach has 22 doubles, a triple, 17 home runs and 52 walks while hitting .253.
• Larnach is 103rd in homers and 113th in RBI in the bigs.
• Larnach heads into this game looking for his fourth game in a row with a hit. During his last five outings he is hitting .176 with a double, a home run, four walks and three RBIs.
• Brooks Lee is hitting .242 with 15 doubles, a triple, 15 home runs and 30 walks.
• Lee is on a two-game hitting streak entering this contest. In his last five games he is batting .353 with a double, a home run, two walks and five RBIs.
• Kody Clemens is hitting .213 with 11 doubles, three triples, 19 home runs and 28 walks.

Twins Team Props

Guardians Recent Betting Performance

• The Guardians have played as underdogs three times over their past 10 games and won each of those contests.
• In their last 10 games with a total, the Guardians and their opponents are 2-8-0 when it comes to hitting the over.
• The Guardians are 8-2-0 ATS over their last 10 games.

Guardians Recent Stats

Guardians Player Insights

• Jose Ramirez leads the Guardians with 29 home runs and 80 runs batted in, while recording a team-best batting average of .282.
• In all of MLB, Ramirez is 22nd in home runs and 40th in RBI.
• Kwan is batting .272 with 27 doubles, a triple, 10 home runs and 53 walks.
• Kwan is 204th in home runs and 169th in RBI among all MLB hitters this year.
• Kyle Manzardo is batting .240 with 17 doubles, two triples, 26 home runs and 47 walks.
• Angel Martinez is hitting .230 with 22 doubles, two triples, 11 home runs and 21 walks.

Guardians Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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Minnesota Twins

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