Twins vs. Astros Prediction, Odds, Picks - April 6

Willi Castro and Jose Altuve will be among the star attractions when the Minnesota Twins play the Houston Astros on Sunday at 2:10 p.m. ET, at Target Field. The Twins are favored in this one, at -116, while the underdog Astros have -103 odds to play spoiler. Houston is the run-line favorite (-1.5). An 8.5-run total has been listed in this contest.

Take a look at everything you need from a betting perspective on the Twins-Astros game, regarding the run line, moneyline and total, plus expert picks.

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Astros vs. Twins Highlights | MLB on FOX

Check out the best highlights between the Houston Astros and the Minnesota Twins.

Twins vs. Astros Game Information & Odds

• When: Sunday, April 6, 2025 at 2:10 p.m. ET
• Where: Target Field in Minneapolis, Minnesota
• How to watch on TV: MNNT and SCHN

Twins vs. Astros Prediction

• Score Prediction: Twins 7, Astros 6
• Total Prediction: Over 8.5 runs
• Win Probabilities: Twins 50%, Astros 50%

Twins vs. Astros Betting Insights

• This season, the Twins have won three out of the eight games in which they've been favored.
• Minnesota is 3-2 this season when entering a game favored by -116 or more on the moneyline.
• The implied probability of a win from the Twins, based on the moneyline, is 53.7%.
• The Astros have been underdogs in three games this season and have come away with the win one time (33.3%) in those contests.
• Houston has a mark of 1-2 in contests where sportsbooks favor it by -103 or worse on the moneyline.
• The moneyline set for this matchup implies the Astros have a 50.7% chance of walking away with the win.

Twins Player Insights

• Harrison Bader has accumulated a team-high three home runs and eight runs batted in.
• Castro has three doubles, a home run and two walks while batting .231.
• Castro ranks 75th in home runs and 116th in RBI among all MLB hitters this season.
• Byron Buxton is batting .214 with a double, a home run and a walk.
• Matt Wallner has three doubles, a triple and five walks while batting .160.
• Wallner is riding a two-game hitting streak into this one. In his last five games he is hitting .235 with three doubles, a triple, four walks and an RBI.

Twins Team Props

Astros Player Insights

• Jeremy Pena has hit a team-high two home runs.
• Among all hitters in MLB, Pena's home run total is 37th and his RBI tally is 172nd.
• Altuve has showcased his ability as a power hitter this season, as he paces his team with two home runs with a club-leading .364 batting average.
• Among all MLB hitters, Altuve ranks 37th in home runs and 172nd in RBI.
• Brendan Rodgers is hitting .316 with two doubles and three walks.
• Isaac Paredes is hitting .148 with a double and five walks.

Astros Team Props

Astros vs. Twins Highlights | MLB on FOX

Check out the best highlights between the Houston Astros and the Minnesota Twins.

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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