Giants vs. Royals Prediction, Odds, Picks - May 21

Wilmer Flores and the San Francisco Giants will play Maikel Garcia and the Kansas City Royals on Wednesday at Oracle Park, at 3:45 p.m. ET. Bookmakers list the Giants as -136 moneyline favorites, while giving the underdog Royals +115 moneyline odds to win. San Francisco (-1.5) is favored on the run line. The over/under is 7.5 runs for this matchup (with -113 odds on the over and -107 odds to go under).

Here's everything you need to know from a betting perspective on the Giants-Royals game, regarding the run line, moneyline and total, plus expert picks.

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Giants vs. Royals Game Information & Odds

• When: Wednesday, May 21, 2025 at 3:45 p.m. ET
• Where: Oracle Park in San Francisco, California
• How to watch on TV: NBCS-BA and FDSKC

Giants vs. Royals Prediction

• Score Prediction: Giants 4, Royals 3
• Total Prediction: Under 7.5 runs
• Win Probabilities: Giants 58%, Royals 42%

Giants vs. Royals Betting Insights

• The Giants have won 19, or 65.5%, of the 29 games they've played as favorites this season.
• San Francisco is 16-5 this season when entering a game favored by -136 or more on the moneyline.
• Bookmakers have implied with the moneyline set for this matchup that the Giants have a 57.6% chance to win.
• The Royals have come away with 14 wins in the 29 contests they have been listed as the underdogs in this season.
• This season, Kansas City has come away with a win seven times in 14 chances when named as an underdog of at least +115 or worse on the moneyline.
• The moneyline set for this matchup implies the Royals have a 46.5% chance of walking away with the win.

Giants Recent Betting Performance

• The Giants were the moneyline favorite for six of their last 10 games, and finished 4-2 in those matchups.
• In their last 10 matchups, the Giants and their opponents combined to hit the over on the run total four times (all 10 games had set totals).
• The Giants have gone 5-5-0 against the spread over their past 10 games.

Giants Recent Stats

Giants Player Insights

• Jung Hoo Lee is hitting .275 with 13 doubles, two triples, six home runs and 11 walks.
• Lee's home runs place him 81st in MLB, and he ranks 20th in RBI.
• Lee has collected a hit in two straight games. In his last five games he is batting .190 with two doubles and two RBIs.
• Flores has hit 10 home runs with 42 RBI. Both are team-highs.
• Flores is 19th in homers and third in RBI among all hitters in the majors.
• Flores has two straight games with at least one hit. During his last five outings he is batting .294 with three home runs, five walks and nine RBIs.
• Heliot Ramos paces the Giants with a team-high batting average of .293.
• Ramos has at least one base hit in six games in a row. In his last 10 games he is batting .457 with two doubles, three home runs, four walks and 10 RBIs.
• Matt Chapman has seven doubles, eight home runs and 31 walks while hitting .216.

Giants Team Props

Royals Recent Betting Performance

• The Royals have played as underdogs in six of their past 10 games and won three of those contests.
• In their last 10 games with a total, the Royals and their opponents are 3-7-0 when it comes to hitting the over.
• The Royals have seven wins against the spread in their last 10 chances.

Royals Recent Stats

Royals Player Insights

• Bobby Witt Jr. is batting .301 with 18 doubles, three triples, five home runs and 19 walks, while getting on base at a rate of .367.
• Among all batters in the majors, Witt is 117th in home runs and 49th in RBI.
• Garcia is batting .310 to lead the lineup.
• Among all MLB hitters, Garcia ranks 117th in homers and 105th in RBI.
• Vinnie Pasquantino leads the Royals in home runs (eight) and runs batted in (28).
• Jonathan India is batting .234 with 10 doubles, a home run and 22 walks.

Royals Team Props

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FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

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