Penn State vs. Michigan State Prediction, Odds, Picks - November 15, 2025

Updated Nov. 15, 2025 3:04 p.m. ET

FOX Sports

The Penn State Nittany Lions (3-6) and the Michigan State Spartans (3-6) clash with the Land Grant Trophy up for grabs on Saturday, November 15, 2025 at Spartan Stadium. The Nittany Lions are favored by 7 points in the contest. The total is 49.5 points for this game.

Last time out, the Nittany Lions fell to the Indiana Hoosiers, with 27-24 being the final score. The Spartans lost against the Minnesota Golden Gophers in their last game, 23-20.

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Penn State vs. Michigan State Game Information & Odds

When: Saturday, November 15, 2025 at 3:30 p.m. ET
Location: Spartan Stadium in East Lansing, Michigan
TV: CBS
Live Box Score on FOX Sports

Penn State vs Michigan State Betting Information updated as of November 15, 2025, 2:45 p.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Penn State	-7 (-114)	-267	+216	49.5	-107	-116

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Penn State vs. Michigan State Prediction

Pick ATS: Michigan State (+7)
Pick OU: Over (49.5)
Prediction: Penn State 30, Michigan State 25

Predictions are made by the Data Skrive betting model.

Learn more about the Penn State Nittany Lions vs. the Michigan State Spartans game on FOX Sports!

Penn State vs. Michigan State Betting Insights

Per the spread and over/under, the implied score for the tilt is Nittany Lions 28, Spartans 21.
The Nittany Lions have a 72.8% chance to win this game based on the moneyline's implied probability. The Spartans have a 31.6% implied probability.
Penn State has a record of just 2-7-0 against the spread this season.
Michigan State has compiled a 5-4-0 record against the spread this year.

Penn State vs. Michigan State: Head-to-Head

Penn State holds a 2-1 record against Michigan State in their last three matchups.
In their past three meetings, each team has covered one time (one push) with those games outscoring the total on one occasion.
Michigan State has been outpaced by 58 points in its last three tilts against Penn State.

Penn State vs. Michigan State: 2025 Stats Comparison

	Penn State	Michigan State
Off. Points per Game (Rank)	30.7 (57)	25.6 (92)
Def. Points per Game (Rank)	22.3 (40)	31.4 (109)
Turnovers Allowed (Rank)	10 (41)	9 (23)
Turnovers Forced (Rank)	11 (70)	6 (127)

Penn State 2025 Key Players

Name	Position	Stats
Kaytron Allen	RB	736 YDS / 10 TD / 81.8 YPG / 5.3 YPC
Nicholas Singleton	RB	363 YDS / 9 TD / 40.3 YPG / 3.9 YPC 19 REC / 145 REC YDS / 1 REC TD / 16.1 REC YPG
Drew Allar	QB	1,100 YDS (64.8%) / 8 TD / 3 INT 172 RUSH YDS / 1 RUSH TD / 28.7 RUSH YPG
Trebor Pena	WR	32 REC / 331 YDS / 1 TD / 36.8 YPG
Amare Campbell	LB	66 TKL / 6 TFL / 2 SACK
Zakee Wheatley	DB	61 TKL / 1 TFL / 1 INT / 1 PD
Dani Dennis-Sutton	DL	29 TKL / 5 TFL / 3 SACK
Dominic DeLuca	LB	40 TKL / 4 TFL / 1 SACK

Michigan State 2025 Key Players

Name	Position	Stats
Aidan Chiles	QB	1,392 YDS (63.1%) / 10 TD / 3 INT 227 RUSH YDS / 6 RUSH TD / 28.4 RUSH YPG
Nick Marsh	WR	46 REC / 554 YDS / 5 TD / 61.6 YPG
Makhi Frazier	RB	493 YDS / 2 TD / 61.6 YPG / 4.6 YPC
Omari Kelly	WR	38 REC / 529 YDS / 1 TD / 58.8 YPG
Jordan Hall	LB	69 TKL / 3 TFL / 2 SACK / 1 INT
Malik Spencer	DB	37 TKL / 3 TFL / 2 SACK
Wayne Matthews III	LB	49 TKL / 1 TFL / 1 INT / 1 PD
Armorion Smith	DB	29 TKL / 1 TFL / 1 INT / 1 PD