Ohio vs. Buffalo Prediction, Odds, Picks - November 28, 2025

Updated Nov. 28, 2025 9:04 a.m. ET

FOX Sports

The Ohio Bobcats (7-4) visit the Buffalo Bulls (5-6) on Friday, November 28, 2025 in a matchup between MAC rivals at UB Stadium. Buffalo is a touchdown underdog. A total of 44.5 points has been set for this matchup.

Facing the UMass Minutemen in their most recent game, the Bobcats won 42-14. Last time out, the Bulls fell to the Miami (OH) RedHawks, with 37-20 being the final score.

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Ohio vs. Buffalo Game Information & Odds

When: Friday, November 28, 2025 at 12 p.m. ET
Location: UB Stadium in Buffalo, New York
TV: ESPNU
Live Box Score on FOX Sports

Ohio vs Buffalo Betting Information updated as of November 28, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Ohio	-7 (-110)	-265	+213	44.5	-112	-108

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Ohio vs. Buffalo Prediction

Pick ATS: Ohio (-7)
Pick OU: Over (44.5)
Prediction: Ohio 29, Buffalo 18

Predictions are made by the Data Skrive betting model.

Learn more about the Ohio Bobcats vs. the Buffalo Bulls game on FOX Sports!

Ohio vs. Buffalo Betting Insights

Per the spread and over/under, the implied score for the matchup is Bobcats 26, Bulls 19.
The Bobcats have a 72.6% chance to claim victory in this contest based on the moneyline's implied probability. The Bulls hold a 31.9% implied probability.
Ohio has covered six times in 11 matchups with a spread this season.
Buffalo has put together a 3-7-1 record against the spread this season.

Ohio vs. Buffalo: Head-to-Head

Over their last four meetings, Ohio has totaled three wins against Buffalo.
The Bobcats own a 4-0 record ATS in those games, while the two teams have gone over the point total on two occasions.
In their last four head-to-head matchups, Ohio has scored 138 points versus Buffalo, while giving up only 77 points.

Ohio vs. Buffalo: 2025 Stats Comparison

	Ohio	Buffalo
Off. Points per Game (Rank)	28.5 (62)	23.8 (97)
Def. Points per Game (Rank)	22.6 (49)	22.8 (50)
Turnovers Allowed (Rank)	13 (55)	21 (125)
Turnovers Forced (Rank)	14 (60)	12 (87)

Ohio 2025 Key Players

Name	Position	Stats
Parker Navarro	QB	2,085 YDS (63%) / 12 TD / 9 INT 722 RUSH YDS / 7 RUSH TD / 65.6 RUSH YPG
Sieh Bangura	RB	1,123 YDS / 13 TD / 102.1 YPG / 5.6 YPC
Chase Hendricks	WR	62 REC / 858 YDS / 6 TD / 78 YPG
Duncan Brune	RB	492 YDS / 8 TD / 44.7 YPG / 4.9 YPC
Jalen Thomeson	DB	58 TKL / 3 TFL / 1 INT / 1 PD
Adonis Williams Jr.	DB	58 TKL / 2 TFL
Charlie Christopher	LB	41 TKL / 2 TFL / 1.5 SACK
Michael Molnar	LB	52 TKL / 1 TFL / 1.5 SACK

Buffalo 2025 Key Players

Name	Position	Stats
Victor Snow	WR	58 REC / 733 YDS / 8 TD / 66.6 YPG
Ta'Quan Roberson	QB	2,250 YDS (57.6%) / 15 TD / 11 INT 121 RUSH YDS / 2 RUSH TD / 12.1 RUSH YPG
Al-Jay Henderson	RB	724 YDS / 5 TD / 65.8 YPG / 4.1 YPC 25 REC / 181 REC YDS / 1 REC TD / 22.6 REC YPG
Nik McMillan	WR	56 REC / 853 YDS / 3 TD / 77.5 YPG
Khalil Murdock	LB	95 TKL / 7 TFL / 4.5 SACK
Dion Crawford	LB	55 TKL / 3 TFL / 2.5 SACK
Mitchell Gonser	LB	45 TKL / 2 TFL / 1 SACK / 2 INT
Malin White	DL	38 TKL / 5 TFL / 4 SACK