Michigan vs. Northwestern Prediction, Odds, Picks - November 15, 2025

Updated Nov. 15, 2025 9:04 a.m. ET

Data Skrive

Two of the nation's toughest defenses square off when the No. 18 Michigan Wolverines (7-2) bring college football's 13th-ranked scoring defense into a matchup with the Northwestern Wildcats (5-4), who have the No. 21 scoring defense, on Saturday, November 15, 2025. The Wolverines are heavy, 10.5-point favorites. The contest's point total is set at 41.5.

The Wolverines beat the Purdue Boilermakers, 21-16, in their last contest. In their most recent contest, the Wildcats lost versus the USC Trojans, 38-17.

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Michigan vs. Northwestern Game Information & Odds

When: Saturday, November 15, 2025 at 12 p.m. ET
Location: Wrigley Field in Chicago, Illinois
TV: FOX
Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

Michigan vs Northwestern Betting Information updated as of November 15, 2025, 8:45 a.m. ET.
Favorite	Spread (Odds)	Favorite Moneyline	Underdog Moneyline	Total	Over Moneyline	Under Moneyline
Michigan	-10.5 (-108)	-418	+324	41.5	-111	-109

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Michigan vs. Northwestern Prediction

Pick ATS: Northwestern (+10.5)
Pick OU: Over (41.5)
Prediction: Michigan 25, Northwestern 17

Predictions are made by the Data Skrive betting model.

Learn more about the Michigan Wolverines vs. the Northwestern Wildcats game on FOX Sports!

Michigan vs. Northwestern Betting Insights

Per the spread and over/under, the implied score for the matchup is Wolverines 26, Wildcats 16.
The Wolverines have an 80.7% chance to claim victory in this meeting based on the moneyline's implied probability. The Wildcats have a 23.6% implied probability.
Michigan has put together a 3-6-0 record against the spread this season.
Northwestern has compiled a 5-3-1 record against the spread this season.

Michigan vs. Northwestern: Head-to-Head

In their past two head-to-head contests, Michigan has defeated Northwestern two times.
In those matchups against Northwestern, the Wolverines have covered two times while going over the point total on one occasion.
Northwestern has been outpaced by 70 points in its last two tilts against Michigan.

Michigan vs. Northwestern: 2025 Stats Comparison

	Michigan	Northwestern
Off. Points per Game (Rank)	28.1 (72)	21.9 (112)
Def. Points per Game (Rank)	17.2 (13)	19.1 (20)
Turnovers Allowed (Rank)	8 (13)	15 (102)
Turnovers Forced (Rank)	16 (22)	10 (88)

Michigan 2025 Key Players

Name	Position	Stats
Justice Haynes	RB	857 YDS / 10 TD / 122.4 YPG / 7.1 YPC
Bryce Underwood	QB	1,671 YDS (60.9%) / 7 TD / 3 INT 272 RUSH YDS / 4 RUSH TD / 30.2 RUSH YPG
Jordan Marshall	RB	729 YDS / 8 TD / 81 YPG / 5.9 YPC 7 REC / 74 REC YDS / 0 REC TD / 14.8 REC YPG
Andrew Marsh	WR	25 REC / 376 YDS / 2 TD / 53.7 YPG
Derrick Moore	DL	21 TKL / 6 TFL / 8.5 SACK
Jimmy Rolder	LB	42 TKL / 4 TFL / 2 SACK / 1 INT
Ernest Hausmann	LB	46 TKL / 4 TFL / 1 SACK
Cole Sullivan	LB	19 TKL / 4 TFL / 2 SACK / 3 INT

Northwestern 2025 Key Players

Name	Position	Stats
Caleb Komolafe	RB	726 YDS / 8 TD / 80.7 YPG / 5.1 YPC
Griffin Wilde	WR	43 REC / 593 YDS / 5 TD / 65.9 YPG
Preston Stone	QB	1,522 YDS (59.3%) / 11 TD / 9 INT
Joseph Himon II	RB	397 YDS / 0 TD / 49.6 YPG / 4.9 YPC 19 REC / 115 REC YDS / 0 REC TD / 14.4 REC YPG
Mac Uihlein	LB	60 TKL / 4 TFL / 4 INT / 4 PD
Robert Fitzgerald	DB	69 TKL / 3 TFL
Aidan Hubbard	DL	23 TKL / 5 TFL / 3.5 SACK
Braydon Brus	LB	38 TKL / 1 TFL / 0.5 SACK