College Football Top 25 Week 15 2025 Predictions, Betting Odds & TV Schedule

Top-25 teams will be in action across six games on the Week 15 college football slate. That includes the No. 2 Indiana Hoosiers taking on the No. 1 Ohio State Buckeyes at Lucas Oil Stadium.

For analysis of all the big games in college football this weekend, dive into our betting odds preview below.

Check out the full college football schedule on FOX Sports! Or visit FOX Sports' college football hub for everything you need to make the most of this season’s action.

Week 15 Betting Lines & Game Info

No. 19 James Madison Dukes vs. Troy Trojans

Odds & Prediction

• Spread: Dukes (-24.5)
• Moneyline: Dukes -4000, Trojans +1600
• Total: 47.5 points
• Prediction: James Madison 39, Troy 12

How to Watch

• Game Date: Friday, Dec. 5
• Game Time: 7 p.m. ET
• TV Channel: ESPN
• Location: Harrisonburg, Virginia
• Box Score

No. 21 Tulane Green Wave vs. No. 20 North Texas Mean Green

Odds & Prediction

• Spread: Mean Green (-1.5)
• Moneyline: Mean Green -120, Green Wave +100
• Total: 67.5 points
• Prediction: North Texas 34, Tulane 28

How to Watch

• Game Date: Friday, Dec. 5
• Game Time: 8 p.m. ET
• TV Channel: ABC
• Location: New Orleans, Louisiana
• Box Score

No. 5 Texas Tech Red Raiders vs. No. 11 BYU Cougars

Odds & Prediction

• Spread: Red Raiders (-12.5)
• Moneyline: Red Raiders -521, Cougars +390
• Total: 50.5 points
• Prediction: Texas Tech 30, BYU 22

How to Watch

• Game Date: Saturday, Dec. 6
• Game Time: 12 p.m. ET
• TV Channel: ABC
• Location: Arlington, Texas
• Box Score

No. 10 Alabama Crimson Tide vs. No. 3 Georgia Bulldogs

Odds & Prediction

• Spread: Bulldogs (-1.5)
• Moneyline: Bulldogs -120, Crimson Tide +100
• Total: 48.5 points
• Prediction: Georgia 26, Alabama 24

How to Watch

• Game Date: Saturday, Dec. 6
• Game Time: 4 p.m. ET
• TV Channel: ABC
• Location: Atlanta, Georgia
• Box Score

No. 16 Virginia Cavaliers vs. Duke Blue Devils

Odds & Prediction

• Spread: Cavaliers (-3.5)
• Moneyline: Cavaliers -180, Blue Devils +150
• Total: 58.5 points
• Prediction: Virginia 31, Duke 27

How to Watch

• Game Date: Saturday, Dec. 6
• Game Time: 8 p.m. ET
• TV Channel: ABC
• Location: Charlotte, North Carolina
• Box Score

No. 1 Ohio State Buckeyes vs. No. 2 Indiana Hoosiers

Odds & Prediction

• Spread: Buckeyes (-3.5)
• Moneyline: Buckeyes -192, Hoosiers +160
• Total: 46.5 points
• Prediction: Indiana 25, Ohio State 24

How to Watch

• Game Date: Saturday, Dec. 6
• Game Time: 8 p.m. ET
• TV Channel: FOX
• Location: Indianapolis, Indiana
• Streaming: FOXSports.com, FOX Sports App and FOX One (Try free for 7 days)

FOX Sports created this story using technology provided by Data Skrive and data from Sportradar.

Want great stories delivered right to your inbox?

Create or log in to your FOX Sports account, follow leagues, teams and players to receive a personalized newsletter daily.