It's back out on the road for the D-backs following a 5-1 homestand that pushed their record to 39-26. Thirteen games over .500 is a new high-water mark for the season.
Their 26-9 home record is far and away the best in baseball, but they are just 13-17 on the road, due in large part to an offense that hasn't traveled well. The D-backs are hitting .219 away from Chase Field -- 72 points worse than their average at home.
The Tigers (30-32) are 16-12 at Comerica Park. They are coming off an 8-3 win on Sunday at Boston, halting a three-game losing streak. The D-backs and Tigers split a pair of interleague games at Chase Field in May, but neither of today's starting pitchers were involved.
Greinke is tied with L.A.'s Clayton Kershaw and Colorado's Antonio Senzatela for the most victories in the National League. While many dismiss the importance of that stat, there's no argument that he's pitching like the ace the Diamondbacks thought they were getting when they signed him to a six-year deal in December 2015.
He has amassed 100 strikeouts in 84 1/3 innings while walking just 17. His strikeout rate of 10.67 per nine innings is better than any season in his 14-year career.
Greinke is making his first start since returning from paternity leave. His wife, Emily, gave birth to the couple's second son, Griffin, on Friday.
Greinke has a 13-7 career record and a 2.79 ERA against the Tigers, but he last pitched against them in July 2014. Justin Upton is a .333 career hitter against Greinke, with three home runs in 33 at-bats.
Farmer has been dazzling in two starts since being recalled from Triple-A Toledo in late May. He pitched 6 2/3 scoreless innings against the Angels last Wednesday, holding them to three hits and one walk while striking out five. That came on the heels of 6 1/3 scoreless innings against the White Sox, when he struck out 11 while allowing three hits and two walks.
It hasn't always gone this well for Farmer. He was 0-6 with a 6.84 ERA in 32 major-league appearances prior to this year, and he was 2-3 with a 3.86 ERA at Toledo prior to being called up.
Rick OsentoskiRick Osentoski-USA TODAY Sports
The D-backs are 7-1 against American League competition, which gives them a big leg up on their NL counterparts. Only three other National League teams have winning records in Interleague play -- Colorado (5-4), Milwaukee (4-3) and the Mets (3-2).
All eight of Arizona's Interleague matchups were at Chase Field, so the dynamic changes in an American League park. Torey Lovullo will add a designated hitter to his lineup -- and he was leaning toward using Paul Goldschmidt in that role for at least one of the games.
"I think it would be a nice way for Goldy to play a game and get him off his feet a little bit," Lovullo said.
Goldschmidt hit .444 with a .600 on-base percentage in the just-concluded homestand. As a team, the D-backs hit 11 home runs in six games, with three from Brandon Drury.
Steve MitchellSteve Mitchell-USA TODAY Sports
Scouting the Tigers
The Tigers have added a major force to their lineup since playing in Arizona on May 9-10. Outfielder J.D. Martinez, who was on the disabled list with a foot injury, has hit 10 home runs in 28 games since returning.
But the Tigers have not gotten typical production from perennial All-Star Miguel Cabrera, who is hitting .268 with five home runs in 49 games. He's gone 20 games without a home run, dating back to May 20.
Former D-back Justin Upton leads the team with 13 homers and 40 RBI. Upton had five RBI in Sunday's win over Boston to stretch his hitting streak to 10 games (16 for 39, 4 home runs, 17 RBI). Third baseman Nick Castellanos has homered in three of his last four games and also has a 10-game hitting streak.
The bullpen has been a season-long source of concern for Tigers manager Brad Ausmus. Detroit relievers have a 5.14 cumulative ERA -- 29th in the majors -- and over the past week, they have surrendered 25 hits, 14 walks and 19 earned runs in 19 innings pitched.