Chicago seeks its fourth win in five games when it travels to Atlanta on Saturday night.
Fowles, the WNBA's leading scorer averaging 20.4 points, netted 21 as the Sky (7-7) beat Tulsa 72-54 on Wednesday. The 6-foot-6 center added 13 rebounds, boosting her average to 9.8 - good for third in the league.
Fowles scored 21 points in a 71-68 loss at Atlanta on June 21, but she was held to 10 points with 12 rebounds in an 81-69 home win over the Dream last Saturday.
No matter that last performance, coach Pokey Chatman said Fowles will most always be the No. 1 offensive option.
"You know, sometimes you have to play through Sylvia," Chatman said after Wednesday's win. "That doesn't mean pound the ball in there when there is five people on her. Sometimes it means reverse the ball to get the shooters wide open.
"I like how we got some deflections in the transition. And I like that we involved the entire bench to get some looks, especially going into Atlanta."
If Lyttle returns, she'll provide an inside presence for the Dream (3-9) to help slow Fowles. Lyttle hasn't played since June 14, leaving to play for Spain in an international tournament. The 6-4 forward was on the bench but did not play in a 91-69 road loss to New York on Wednesday.
Regardless of Lyttle's status, the Dream likely will need the same consistent play from Angel McCoughtry.
McCoughtry, averaging 15.5 points, was voted by the fans to start the upcoming All-Star game. She scored 17 points in the last meeting with the Sky, helping stake the Dream to a 22-10 first-quarter lead before Chicago rallied.
McCoughtry led Atlanta with 17 points Wednesday, while veteran guard Coco Miller added 15. Center Erika de Souza was held to five points.
Atlanta has lost six of eight.
"I hope we can get back on the winning track," coach Marynell Meadors said. "We struggled, we didn't play well at all (Wednesday) and we didn't defend well. Those are the things we have to have. We have to come out with more intensity and more effort."
Sky guard Epiphanny Prince scored 24 points last weekend against Atlanta and is averaging 16.6. However, Prince's defense may be her main strength, as she's leading the league averaging 3.1 steals after getting five more Wednesday.
"I am always aggressive in the help side," she said. "My teammates get their hands on a lot of balls and if I can get my hand on it, I always try to pursue the steal."
Chicago had won the previous five meetings in Atlanta before June's loss. Prince scored only 10 points but added four steals.