These Eastern Conference rivals play a home-and-home set in the next three days, beginning Sunday night at Allstate Arena.
New York (16-12) holds a 2-1 lead in the season series, with the home team winning each matchup. The Liberty's 59-49 win Aug. 4 was notable because Chicago (13-15) managed one point in the fourth quarter to set a WNBA record for futility.
The Sky may use a different backcourt than what the Liberty have seen previously. Chicago coach Pokey Chatman debuted the new look there Friday, with former Liberty player Erin Thorn and veteran Dominique Canty starting in place of Epiphanny Prince and rookie Courtney Vandersloot for an 80-67 victory over Washington.
"It's several things," Chatman said. "I thought, conservatively, Dominique's playing well, I thought Erin's done some good things. I think the opponent plays into it. I think it alleviates some pressure with Sloot or with Piph."
Prince is the team's second-leading scorer at 14.4 points per game. She came off the bench for the first time and had 18 points after averaging 9.0 over her previous seven contests.
"I am always ready," Prince said. "I need to stay prepared when my number is called and I always want to try and stay focused."
Prince is averaging 11.3 points and woeful 27.9 percent shooting against New York this season.
She has been outshined in those games by former Rutgers teammate Cappie Pondexter. Pondexter, a Chicago native, is averaging 17.7 points in the season series.
She scored 17 of her 25 points in the fourth quarter Tuesday to lead the Liberty to a 74-70 road win over Phoenix, her former team.
"You have to give credit where credit is due," Mercury coach Corey Gaines said. "That's what Cappie does; she is a finisher. That's what she always did for us."
Pondexter's teams are 14-1 all-time against Chicago.
The Liberty have won three of four and can clinch the tiebreaker over the Sky by taking one of the next two games.
The Sky are trying to reach the playoffs for the first time as they seek to catch the third-place Liberty or fourth-place Atlanta.
"We just need to lock down and be focused," said center Sylvia Fowles, who has a WNBA-high 19 double-doubles. "When we focus we play good as a team and everybody does there part so if we can do that the next couple of games I think we'll be alright."