Ilyasova's absence is a big blow to a Bucks team chasing the Boston Celtics for the seventh spot in the Eastern Conference, as Ilyasova is averaging 17.6 points and 9.3 rebounds per game in his last 16 games.
Luc Richard Mbah a Moute will start at power forward in place of Ilyasova. Mbah a Moute will match-up defensively with former Bucks forward Tobias Harris.
The illness limited Ilyasova against Miami on Tuesday night, as he scored just four points with five rebounds in 21 minutes in Milwaukee's 94-83 loss to the Heat.
The Bucks are a bit shorthanded at power forward as backup Ekpe Udoh is still out with a sprained ankle.
John Henson, Gustavo Ayon and Samuel Dalembert will likely fill the minutes behind Mbah a Moute.
Because of an injury to Jameer Nelson, former Bucks point guard Beno Udrih will start for the Magic against his former team.