"We just weren't able to get that at bat when we needed it tonight," Pirates manager Clint Hurdle said. "Repeatedly."
Charlie Morton (0-2) allowed five runs and eight hits in six innings while losing to Lohse for the second time this week. Russell Martin had two hits and two RBIs for the Pirates, who have lost six of eight.
Four Milwaukee relievers combined to allow five baserunners in 2 2-3 innings but did not allow any runs while stranding six. Francisco Rodriguez worked the ninth for his fifth save in five opportunities.
Lohse's fifth pitch of the game was put in play by Starling Marte -- seemingly for a routine pop-up near the pitcher's mound. But third baseman Aramis Ramirez and first baseman Mark Reynolds collided. It was originally inexplicably ruled a single until later changed by official scorer Evan Pattak to an error on Reynolds.
That wasn't even close to the most memorable wacky play of the game. That came in the sixth inning, when Maldonado literally hit the cover off the ball in what will be one of the more peculiar plays of the season.
Maldonado grounded to third, where Alvarez fielded a ball that's cover had partially ripped off. Alvarez threw the flapping, awkwardly floating ball toward first, but it fell well short of the bag, giving Maldonado an infield single.
"I said to Hurdle, 'You see something new every day, huh?," Lohse said. "He kind of chuckled."
Asked if he'd seen it before, Hurdle said flatly, "Never. Never. Ever."
"It was just one of those games," Brewers manager Ron Roenicke said. "Goofy stuff happened early -- then goofy stuff happened when Maldy hit the cover off the ball. I've never seen that before. We got a run because of it. I don't know. Just a strange game. Hard to explain."
After not getting a runner past first base in their first three innings against Morton, the Brewers got a two-run double from Scooter Gennett and an RBI single from Maldonado in thr fourth to take a lead they didn't relinquish.
A day after scoring nine runs in the seventh and eighth innings, the Pirates pulled to 5-3 in the seventh on Andrew McCutchen's RBI double, but Will Smith came on and struck out cleanup hitter Pedro Alvarez with runners on second and third to end the inning.
The Pirates loaded the bases in the eighth, but Jim Henderson got Starling Marte to pop out to end the threat.
NOTES: Pittsburgh SS Jordy Mercer was removed from the game with what the team called "discomfort" in his right ankle after Maldonado collided with him at second base during the third inning. Mercer stayed in the game the remainder of the inning. ... Less than 15 minutes before first pitch, the Pirates announced they acquired 1B Ike Davis from the New York Mets in exchange for minor-league RHP Zack Thornton and a player to be named. ... Playing each other seven times in a 10-day span, the Pirates and Brewers play the eighth of those meetings Saturday when Pittsburgh LHP Wandy Rodriguez (0-2, 7.31) faces Milwaukee RHP Matt Garza (0-2, 3.43).