WhatIfSports 2016 NFL locks and upset picks

WhatIfSports.com will submit lock and upset picks throughout the 2016 season.

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Each Tuesday, WhatIfSports.com provides NFL predictions for the upcoming week, including straight up and against the spread, using its NFL simulation engine. We break down our performance from previous weeks and offer upset and lock picks for the current week. View our 2015 performance.

Additional weekly NFL content includes player projections and power rankings.

Super Bowl LI

Winning Percentage Straight Up:

Winning Percentage Against the Spread:

Super Bowl LI: Patriots 25 vs. Falcons 24 – 55.3 win%

View Super Bowl LI Pick

NFL Conference Championships

Winning Percentage Straight Up: 100.0% (2-0)

Winning Percentage Against the Spread: 0.0% (0-2)

Game to Watch: Packers 23 @ Falcons 27 – 65.4 win% (correct, Falcons won 44-21)

Lock Pick: Falcons over Packers – 65.4 win% SU (correct, Falcons won 44-21)

Against the Spread Pick: Steelers (+6) cover against Patriots (incorrect, Patriots won 36-17)

View Conference Championship NFL Picks

NFL Divisional Round

Winning Percentage Straight Up: 75.0% (3-1)

Winning Percentage Against the Spread: 50.0% (2-2)

Game to Watch: Seahawks 24 @ Falcons 26 – 57.1 win% (correct, Falcons won 36-20)

Lock Pick: Patriots over Texans – 61.3 win% SU (correct, Patriots won 34-16)

Against the Spread Pick: Steelers (+1.5) cover against Chiefs (correct, Steelers won 18-16)

View Divisional NFL Picks

NFL Wild Card Round

Winning Percentage Straight Up: 75.0% (3-1)

Winning Percentage Against the Spread: 0.0% (0-4)

Game to Watch: Seahawks 26 @ Lions 23 – 58.3 win% (correct, Seahawks won 26-6)

Lock Pick: Steelers over Dolphins – 58.8 win% SU (correct, Steelers won 30-6)

Against the Spread Pick: Giants (+4.5) cover against Packers (incorrect, Packers won 38-13)

View Wild Card NFL Picks

NFL Week 17

Winning Percentage Straight Up: 68.8% (11-5)

Winning Percentage Against the Spread: 42.9% (6-8)

Game to Watch: Packers 24 @ Lions 22 – 54.1 win% (correct, Packers won 31-24)

Lock Pick: Seahawks over 49ers – 80.4 win% SU (correct, Seahawks won 25-23)

Against the Spread Pick: Ravens (+2.5) cover against Bengals (incorrect, Bengals won 27-10)

View Week 17 NFL Picks

NFL Week 16

Winning Percentage Straight Up: 56.3% (9-7)

Winning Percentage Against the Spread: 45.5% (5-6)

Game to Watch: Ravens 22 @ Steelers 25 – 58.6 win% (correct, Steelers won 31-27)

Lock Pick: Patriots over Jets – 80.0 win% SU (correct, Patriots won 41-3)

Against the Spread Pick: Buccaneers (+3) cover against Saints (incorrect, Saints won 31-24)

View Week 16 NFL Picks

NFL Week 15

Winning Percentage Straight Up: 81.3% (13-3)

Winning Percentage Against the Spread: 70.8% (8-3-1)

Game to Watch: Lions 20 @ Giants 27 – 68.1 win% (correct, Giants won 17-6)

Lock Pick: Bills over Browns – 78.9 win% SU (correct, Bills won 33-13)

Against the Spread Pick: Colts (+4) cover against Vikings (correct, Colts won 34-6)

View Week 15 NFL Picks

NFL Week 14

Winning Percentage Straight Up: 62.5% (10-6)

Winning Percentage Against the Spread: 50.0% (5-5-1)

Game to Watch: Texans 24 @ Colts 25 – 53.4 win% (incorrect, Texans won 22-17)

Lock Pick: Lions over Bears – 68.2 win% SU (correct, Lions won 27-21)

Against the Spread Pick: Broncos (+1) cover against Titans (incorrect, Titans won 13-10)

View Week 14 NFL Picks

NFL Week 13

Winning Percentage Straight Up: 73.3% (11-4)

Winning Percentage Against the Spread: 50.0% (6-6)

Game to Watch: Giants 24 @ Steelers 26 – 58.3 win% (correct, Steelers won 24-14)

Lock Pick: Patriots over Rams – 75.1 win% SU (correct, Patriots won 26-10)

Against the Spread Pick: Redskins (+2.5) cover against Cardinals (incorrect, Cardinals won 31-23)

View Week 13 NFL Picks

NFL Week 12

Winning Percentage Straight Up: 75.0% (12-4)

Winning Percentage Against the Spread: 68.2% (7-3-1)

Game to Watch: Panthers 19 @ Raiders 25 – 68.4 win% (correct, Raiders won 35-32)

Lock Pick: Giants over Browns – 78.4 win% SU (correct, Giants won 27-13)

Against the Spread Pick: Titans (-4.5) cover against Bears (correct, Titans won 27-21)

View Week 12 NFL Picks

NFL Week 11

Winning Percentage Straight Up: 71.4% (10-4)

Winning Percentage Against the Spread: 45.8% (5-6-1)

Game to Watch: Eagles 18 @ Seahawks 24 – 68.1 win% (correct, Seahawks won 26-15)

Lock Pick: Patriots over 49ers – 79.4 win% SU (correct, Patriots won 30-17)

Against the Spread Pick: Titans (+3) cover against Colts (incorrect, Colts won 24-17)

View Week 11 NFL Picks

NFL Week 10

Winning Percentage Straight Up: 57.1% (8-6)

Winning Percentage Against the Spread: 63.6% (7-4)

Game to Watch: Cowboys 27 @ Steelers 24 – 63.3 win% (correct, Cowboys won 35-30)

Lock Pick: Cardinals over 49ers – 72.1 win% SU (correct, Cardinals won 23-20)

Against the Spread Pick: Chiefs (+3) cover against Panthers (correct, Chiefs won 20-17)

View Week 10 NFL Picks

NFL Week 9

Winning Percentage Straight Up: 69.2% (9-4)

Winning Percentage Against the Spread: 66.7% (8-4)

Game to Watch: Eagles 19 @ Giants 21 – 57.3 win% (correct, Giants won 28-23)

Lock Pick: Cowboys over Browns – 79.8 win% SU (correct, Cowboys won 35-10)

Against the Spread Pick: Steelers (+1) cover against Ravens (incorrect, Ravens won 21-14)

View Week 9 NFL Picks

NFL Week 8

Winning Percentage Straight Up: 73.1% (9-3-1)

Winning Percentage Against the Spread: 38.9% (3-5-1)

Game to Watch: Chiefs 27 @ Colts 23 – 62.3 win% (correct, Chiefs won 30-14)

Lock Pick: Vikings over Bears – 78.6 win% SU (incorrect, Bears won 20-10)

Against the Spread Pick: Cardinals (+3) cover against Panthers (incorrect, Panthers won 30-20)

View Week 8 NFL Picks

NFL Week 7

Winning Percentage Straight Up: 56.7% (8-6-1)

Winning Percentage Against the Spread: 34.6% (4-8-1)

Game to Watch: Seahawks 27 @ Cardinals 24 – 57.5 win% (Seahawks and Cardinals tied 6-6)

Lock Pick: Bengals over Browns – 67.0 win% SU (correct, Bengals won 31-17)

Against the Spread Pick: Redskins (+1) cover against Lions (incorrect, Lions won 20-17)

View Week 7 NFL Picks

NFL Week 6

Winning Percentage Straight Up: 46.7% (7-8)

Winning Percentage Against the Spread: 42.9% (5-7-2)

Game to Watch: Falcons 24 @ Seahawks 25 – 53.4 win% (correct, Seahawks won 26-24)

Lock Pick: Steelers over Dolphins – 76.6 win% SU (incorrect, Dolphins won 30-15)

Against the Spread Pick: Jaguars (+2.5) cover against Bears (correct, Jaguars won 17-16)

View Week 6 NFL Picks

NFL Week 5

Winning Percentage Straight Up: 50.0% (7-7)

Winning Percentage Against the Spread: 45.5% (5-6)

Game to Watch: Bengals 23 @ Cowboys 20 – 59.5 win% (incorrect, Cowboys won 28-14)

Lock Pick: Patriots over Browns – 90.4 win% SU (correct, Patriots won 33-13)

Against the Spread Pick: Eagles (-3.0) cover the spread 71.1% vs. Lions (incorrect, Lions won 24-23)

View Week 5 NFL Picks

NFL Week 4

Winning Percentage Straight Up: 53.5% (8-7)

Winning Percentage Against the Spread: 75.0% (6-2)

Game to Watch: Chiefs 23 @ Steelers 24 – 52.7 win% (correct, Steelers won 43-14)

Lock Pick: Redskins over Browns – 75.8 win% SU (correct, Redskins won 31-20)

Against the Spread Pick: Broncos (-3.0) cover the spread 64.5% vs. Buccaneers (correct, Broncos won 27-7)

View Week 4 NFL Picks

NFL Week 3

Winning Percentage Straight Up: 62.5% (10-6)

Winning Percentage Against the Spread: 50.0% (8-8)

Game to Watch: Vikings 18 @ Panthers 22 – 60.8 win% (incorrect, Vikings won 22-10)

Lock Pick: Dolphins over Browns – 81.2 win% SU (correct, Dolphins won 30-24)

Upset Pick: Raiders (+1.5) cover against Titans (correct, Raiders won 17-10)

View Week 3 NFL Picks

NFL Week 2

Winning Percentage Straight Up: 50.0% (8-8)

Winning Percentage Against the Spread: 27.3% (3-8)

Game to Watch: Buccaneers 22 @ Cardinals 28 – 70.6 win% (correct, Cardinals won 40-7)

Lock Pick: Panthers over 49ers – 81.9 win% SU (correct, Panthers won 46-27)

Upset Pick: Jaguars (+3) cover against Chargers (incorrect, Chargers won 38-14)

View Week 2 NFL Picks

NFL Week 1

Winning Percentage Straight Up: 56.3% (9-7)

Winning Percentage Against the Spread: 46.2% (6-7)

Game to Watch: Giants 26 @ Cowboys 23 – 58.5 win% (correct, Giants won 20-19)

Lock Pick: Chiefs over Chargers – 80.1 win% SU (correct, Chiefs won 33-27)

Upset Pick: Jets (+2.5) cover against Bengals (correct, Bengals won 23-22)

View Week 1 NFL Picks

Note: Any pick below 52.5% to win ATS is a NO PICK