For the second straight year, Serena held off Azarenka in the final in Flushing Meadows. The wind-swept, three-set affair went 7-5, 6-7 (6), 6-1 to the American. The title left her one shy of Martina Navratilova and Chris Evert on the all-time list, in sixth place overall.
It's a celebratory scene that's become commonplace since 1999, when Serena Williams won her first Grand Slam singles title at the US Open at the age of 17. With her recent run at Wimbledon, the Olympics and the US Open, Serena seemingly is playing better than ever. Click through to relive her 15 Grand Slam singles triumphs.
No. 1: 1999 U.S. Open
Just 17 years old, Serena Williams made her arrival on the Grand Slam stage at her home nation's major, beating world No. 1 Martina Hingis in the final 6-3, 7-6 (4). She also beat No. 2 Lindsay Davenport and No. 4 Monica Seles en route to the championship.
No. 2: 2002 French Open
Serena waited out nine Grand Slams before returning to the winner's circle with this win in Paris, the longest drought in her career. The French Open crown — a 7-5, 6-3 win over her sister, Venus — is still her only title at the clay-court Slam.
No. 3: 2002 Wimbledon
Serena pulled off the French-Wimbledon double with a 7-6 (4), 6-3 win, again over sister Venus. It was Serena's first success on the grass courts of the All England Club, with many more to come.
No. 4: 2002 U.S. Open
Serena got back at Venus for the 2001 U.S. Open final, which Venus won. Little sister took the 2002 version 6-4, 6-3, her second title in New York.
No. 5: 2003 Australian Open
In probably their most competitive final, Serena again beat Venus for the title, this time in three sets. Serena won 7-6 (4), 3-6, 6-4 to capture her first title Down Under. The win also capped her "Serena Slam" — after this title, she was the current holder of all four major championships.
No. 6: 2003 Wimbledon
Serena conquered Wimbledon for a second straight year, beating Venus in the final 4-6, 6-4, 6-2 — one of only two three-set Slam finals the sisters have played in eight meetings. It was also Serena's sixth straight Slam final against her sister.
No. 7: 2005 Australian Open
Davenport competed in seven Grand Slam finals, but this was the only one against Serena. After getting shown up in the first set, Serena rallied for a 2-6, 6-3, 6-0 to take her second title in Melbourne.
No. 8: 2007 Australian Open
Serena was at her heavy-hitting best in Melbourne, obliterating Maria Sharapova 6-1, 6-2 in the final to end a two-year Slam drought. The win also got revenge for the 2004 Wimbledon final, which Serena lost to the up-and-coming Russian.
No. 9: 2008 U.S. Open
One of her best tournament showings, Serena was rarely challenged — except, of course, by Venus in the quarterfinals — and won the title without dropping a set. The No. 4 seed beat Jelena Jankovic 6-4, 7-5 in the final for her third title in New York.
No. 10: 2009 Australian Open
Serena continued her run of success in odd years at the 2009 Australian Open, winning her fourth title in Australia with a thorough 6-0, 6-3 beating of Dinara Safina.
No. 11: 2009 Wimbledon
Serena improved to 6-2 against her sister in Grand Slam finals with a 7-6 (3), 6-2 win over Venus. But Serena almost didn't even make it to this one — she survived a classic semifinal against Elena Dementieva in the previous match.
No. 12: 2010 Australian Open
Serena and Justine Henin had combined to make 25 Grand Slam finals prior to the 2010 Australian Open, but amazingly, they had never faced each other until this one. Henin — who had recently come out of retirement — pushed Serena to a third set, but the American came through 6-4, 3-6, 6-2 for her fifth title in Melbourne.
No. 13: 2010 Wimbledon
Playing one of the best finals of her career, Serena floated back and forth across the court in a relatively easy 6-4, 6-3 win over first-time finalist Vera Zvonareva. It was Serena's fourth Wimbledon title and vaulted her past Billie Jean King on the all-time Grand Slam title list.
No. 14: 2012 Wimbledon
Serena Williams holds the Wimbledon champions trophy once again after defeating Poland's Agnieszka Radwanska 6-1, 5-7, 6-2. This was Serena's fifth Wimbledon singles title — culminating a long comeback from injury and tying her with sister Venus.
No. 15: 2012 US Open
Serena gets a hug from world No. 1 Victoria Azarenka after receiving her trophy following her fourth career Open victory — 13 years after her first. “Three decades — the 90’s, the 2000’s and 2010’s — that’s kinda cool,” she said.
No. 16: 2013 French Open
After an 11-year gap, Serena returned to the top in Paris, beating defending champion Maria Sharapova 6-4, 6-4 in the final to win her second title at Roland Garros and first since 2002. The win was also Serena's 31st straight in a run of dominance that had some suggesting it was the best tennis of her career.