On Friday, it looked as if Lorenzo was back in top form as he set a blazing lap of 2:02.734, two tenths quicker than Marquez.
Championship contender Dani Pedrosa trailed in third followed by 2012 pole-sitter Alvaro Bautista. Valentino Rossi, who has captured three premier class wins at Silverstone, rounded out the top five.
Home favorite Cal Crutchlow finished the day in sixth ahead of Andrea Dovizioso, Bradley Smith, Stefan Bradl and Nicky Hayden.
Riders will be back on track Saturday morning at 4:55a ET for Free Practice 3, followed by Free Practice 4 at 8:30a and qualifying 9:10a. Both FP4 and Qualifying can be seen Live on SPEED2.com.
Free Practice 2 Results:
1. Jorge Lorenzo (SPA) Yamaha 2:02.734
2. Marc Marquez (SPA) Repsol Honda 2:02.958
3. Dani Pedrosa (SPA) Repsol Honda 2:03.192
4. Alvaro Bautista (SPA) Gresini Honda 2:03.463
5. Valentino Rossi (ITA) Yamaha 2:03.480
6. Cal Crutchlow (GBR) Tech 3 Yamaha 2:03.505
7. Andrea Dovizioso (ITA) Ducati 2:03.658
8. Bradley Smith (GBR) Tech 3 Yamaha 2:03.750
9. Stefan Bradl (GER) LCR Honda 2:03.784
10. Nicky Hayden (USA) Ducati 2:04.089
11. Aleix Espargaro (SPA) Aspar ART 2:04.145
12. Yonny Hernandez (COL) Paul Bird ART 2:04.476
13. Andrea Iannone (ITA) Pramac Ducati 2:05.052
14. Randy de Puniet (FRA) Aspar ART 2:05.069
15. Hector Barbera (SPA) Avintia Blusens FTR 2:05.266British GP, Jorge Lorenzo, Marc Marquez, MotoGP, Silverstone