Yet the way Spain collapsed against the Dutch will not be forgotten any time soon by anyone connected to the squad.
"We knew Holland were going to be a permanent danger and we weren't able to stop them," Del Bosque said.
"We are badly accustomed to always having the result in our favor. We have to be prepared to face adversity but it's not easy. Against Holland we got a painful punishment.
"We are sportsmen and we have no choice but to lift ourselves up. We have to fight in the next game which is our aim. We need to accept defeat with patience and tranquility. This is what I've tried to transmit to the team."
Del Bosque's team defeated Chile 2-1 in the group stages of the 2010 World Cup in South Africa, having lost their opener against Switzerland 1-0.
The difference this time, however, is that Spain are coming off their worst ever result in the competition.
"We have enough experience," Del Bosque said, "and we have to combat their way of playing because Chile are a team that puts a lot of dangerous pressure."