Pellegrini’s most immediate concern is overcoming the absence of his captain Vincent Kompany and all three of his frontline strikers for the visit of Crystal Palace in the Barclays Premier League on Saturday.
Kompany suffered a recurrence of a hamstring injury in his comeback match at Leicester last week while forward Edin Dzeko hurt his calf in the warm-up. Frontmen Sergio Aguero and Stevan Jovetic were already sidelined.
The lack of forward options could mean another opportunity for 18-year-old Jose Angel Pozo or a change of system to utilise a midfielder such as Milner, David Silva or Samir Nasri in an advanced position.
Pellegrini said: "The strikers, the three of them are out for tomorrow. We will try to play in another way.
"I hope that midfielders will arrive from the second line and we will score in another way.
"I know that we play against a team that defend very well also so we will see what is the best solution to play without them."
Victory for City by four goals or more would take the defending champions back to the top of the table ahead of current leaders Chelsea’s trip to Stoke on Monday.
Pellegrini said: "That is very important – not for the pressure we can put on Chelsea but it is very important to add three more points and to finish the first round of games with the most amount of points we can.
"We cannot drop any more points here at home because we already dropped the same number of points we did last season."
But Pellegrini is not taking anything for granted, remembering a difficult home clash with Palace at the same time last year.
He said: "It was a very tough game. It was just after Boxing Day. We won 1-0 and Edin Dzeko scored. I am sure tomorrow we will have a similar game that we had last year."