Kyle Walker (pelvis), Ross Barkley (knee), Theo Walcott (knee), Glen Johnson (thigh), Luke Shaw (hamstring), Michael Carrick (ankle), Jon Flanagan (knee), Adam Lallana (knee), Chris Smalling (groin), Kieran Gibbs (hamstring), Jay Rodriguez (knee) and Andy Carroll (ankle) are all missing through injury.
And with Steven Gerrard, Frank Lampard and Ashley Cole having now retired, there is an obvious lack of experience in the squad, which is set to meet on Sunday night.
And while Hodgson admits injuries played a part in his thinking when naming the possible debutants, he is not worried about their lack of experience
"I don't see any reason for us to be fearful in any way but on the other hand I think it will be exciting and, to some extent, anxious moments for us all to see how these players can step up," he added.
"Unfortunately you don't put things behind you, memories stay with you. We were so bitterly disappointed at the way we we exited the World Cup. We went there with such high hopes, we were so desperate to play well.
"I am very excited about the prospect of this England group but I was that before the World Cup.
"And even more so now perhaps after the World Cup because it's obvious now that these players have got to do the job because they don't have the senior figures to lead them.
"The only player they have now, Glen Johnson has 50 caps.