The Ivory Coast forward set Arsenal on its way with the opener in the 11th minute and then provided assists for Santi Cazorla and Olivier Giroud to net in the second half.
Hal Robson-Kanu pulled a goal back for Reading, but Mikel Arteta ended the struggling visitors’ hopes of an unlikely comeback by slotting home a penalty 13 minutes from time.
The victory lifts Arsenal to within two points of fourth-place Chelsea and drops Reading provisionally bottom of the table after Adkins’ first game in charge of the club.
”I thought Arsenal were very good, they’ve passed the ball very well,” said Adkins, who was fired by Southampton in January. "Unfortunately, we’ve made our own downfall on a couple of goals.”
The Emirates Stadium wasn’t exactly an ideal venue for Adkins to resume his coaching career, with Arsenal full of confidence after back-to-back 2-0 wins against Bayern Munich and Swansea before the international break.
And Gervinho, back in favor at Arsenal following a mid-season slump in form, continued the team’s momentum by smashing in from close range after Cazorla drove in a cross. The Ivory Coast forward also scored against Swansea.
”He was always lively and created many dangerous situations,” Wenger said of the much-maligned Gervinho.
Cazorla, the instigator of many Arsenal attacks, clipped in a great finish from the edge of the area in the 48th after being picked out by Gervinho, who then led a counter-attack in the 68th and passed for Giroud to drill home low to make it 3-0.
Robson-Kanu stooped to head in a cross from the left a minute later, with Arsenal left back Nacho Monreal having to go off after injuring his knee in the build-up to the goal.
But Arteta ensured there were no late anxieties for the hosts by calmly stroking in a penalty after Alex Oxlade-Chamberlain was fouled.
”We played with good collective spirit, technical quality and always went forward,” Wenger said. ”We created many chances, that’s the most pleasant thing. We defended well, had good discipline and didn’t become easy when the game became easy.”
Arsenal is four points behind third-place Tottenham with a game in hand.