Can Toronto FC stop Landon Donovan and Co. at StubHub Center (live, Sunday, 10:30 p.m. ET)
Reasons to watch: The odds are not in the Reds' favor given the cross-country flight and the marauding form displayed by the home side in recent weeks. The return of Jermain Defoe could help matters, though the extent of his participation remains in some doubt. TFC's route to a result here is straightforward and staggeringly difficult: blunt the Galaxy's movement in the attacking third, get Michael Bradley on the ball to counter quickly and trust Bradley to elude Juninho and Marcelo Sarvas just long enough to play a ball over the top to Defoe or some other willing runner. Anything less will allow the Galaxy to claim the points and pile all sorts of pressure on the Reds ahead of Wednesday's visit by Houston (Source: Inside MLS Blog)
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Dortmund hope to revive its Bundesliga campaign against Hamburg (live, Saturday, 9:30 a.m. ET)
Reasons to watch: A convicing 3-0 victory at Anderlecht on Wednesday continued Dortmund's Champions League start. The same cannot be said about BVB's start to the Bundesliga campaign, having already fallen seven points from leaders Bayern Munich. Dortmund can ill-afford to lose any further ground and Hamburg seem to be the perfect remedy this weekend. If Jurgen Klopp's crew fail to secure three points, expect grumblings to continue from the Die Borussen diehards.
Bongarts/Getty ImagesAlex Grimm
Barcelona look to bounce back from PSG drubbing vs. Rayo Vallecano (live, Saturday, 12 p.m. ET)
Reasons to watch: The midweek Champions League loss to Paris Saint-Germain brought the Camp Nou faithful back to earth but a trip to Vallecano is maybe what Luis Enrique's team needs at this point. Sitting pretty atop La Liga with 16 points from a possible 18, Barca can rediscover their mojo and move further ahead of Valencia and Atletico Madrid in the table. And, oh, Lionel Messi can break another record by equaling or breaking the Spanish league's all-time scoring record, a milestone that has stood untouched for almost 60 years. Need we say more?
AFP/Getty ImagesLLUIS GENE
Real Madrid aim to keep pace with La Liga leaders with test vs. Athletic Bilbao (live, Sunday, 3 p.m. ET)
Reasons to watch: Los Blancos survived a European scare, coming from behind to defeat Champions League darlings Ludogorets 2-1 in Bulgaria. The road doesn't get any easier for Carlo Ancelotti's men, either. Athletic Bilbao come to the Santiago Bernabeu, eager to wash the 2-1 loss to BATE out their mouths. If Real are to challenge Barcelona and Atletico Madrid for the Primera Division crown, they cannot drop precious home points to a club riding a six-match winless streak.
AFP/Getty ImagesJOSE JORDAN
River Plate, Boca Juniors lock horns amid Argentina's economic, social problems (live, Sunday, 4:15 p.m. ET)
Reasons to watch: The Superclasico is always a special event and it will take added meaning this year. Despite the Argentine government banning visiting fans from attending away games in an effort to stem endemic violence and hooliganism, 3,000 police and security guards are still expected at Estadio Monumental River leads the Primera Division with 21 points, eight clear of eternal rival Boca. One way or another, expect fireworks come Sunday.
Tottenham take on surprise package Southampton (live, Sunday, 9:05 p.m. ET)
Reasons to watch: This is the Mauricio Pochettino show. The Argentine joined Spurs in May after 16 months as coach of Southampton, an act which didn’t go down too well with Saints fans. However, things are looking bright for the club on the south coast of England who looked like they wouldn’t even be able to field a starting XI at the start of the season. Incredibly, Ronaldo Koeman brings his side to White Hart Lane second in the table despite losing Adam Lallana, Luke Shaw, Rickie Lambert, Dejan Lovren and Callum Chambers to bigger clubs. In Graziano Pelle, they have one of the finds of the season and keeping Morgan Schneiderlin has proved unstrumental to their great start. How will Pochettino fare against his former club? Watch the drama unfold.
Premier League leaders Chelsea take on London rivals Arsenal (live, Sunday, 9:05 a.m. ET)
Reasons to watch: Chelsea are already starting to look like the real deal. Five wins and a draw from their first six games has put them top of the Premier League table and in star striker Diego Costa they seem to have found the missing ingredient from last season. They’re going well in the Champions League, too. Jose Mourinho’s men are six points clear of London rivals Arsenal but this is a fight between the only sides yet to lose a game in the Premier League. The Gunners’ problem? They draw too many games. This is THE match to watch in the Premier League this weekend.
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Manchester United meet Everton at Old Trafford (live, Sunday, 7 a.m. ET)
Reasons to watch: An outsider looking at the Premier League table may wonder what all the fuss is about United’s slow start to the season but don’t be fooled by their position. Eighth may look good for a team that finished seventh last season, but this is a side in crisis. An injury-hit and leaky defense, no Wayne Rooney after his idiotic dismissal against West Ham and now no Ander Herrera, either. Juan Mata looks set to start in place of former Everton forward Rooney. The good news for United is that they face an Everton side with just one win from their first six games. These two teams are already fighting for fourth spot.
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Paris Saint-Germain take on Monaco in Ligue 1 (live, Sunday, 3 p.m. ET)
Reasons to watch: Last season this would have been a battle between first and second but how things have changed. PSG are still being bankrolled by uber-rich Qatari owners made a big statement in midweek when they beat Barcelona -- without Zlatan Ibrahimovic. They haven’t been firing on all cylinders in Ligue 1 but after eight games they remain unbeaten and in fourth spot -- five points off leaders Marseille. How times have changed for Monaco. Their Russian owner sold James Rodriguez to Real Madrid and loaned out Radamel Falcao to Manchester United. If they are to have any chance of getting back into the title race they must not lose in Paris.
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Juventus and Roma clash in a perfect storm (live, Sunday, 12 p.m. ET)
Reasons to watch: If you had to watch just one match in Europe this weekend this would be it. Both teams have started like a house on fire, winning their opening five games to make this match an early indicator of where the Scudetto could be heading at the end of the season. Their defenses are incredible, too. Roma, who dominated Manchester City in the Champions League in midweek (all hail Francesco Totti!), have let in just one goal. Juve? They are top on account of their superior goal difference and have yet to concede this season. Two brilliant sides. Something’s gotta give.