Manchester City face Chelsea at Etihad Stadium (live, Sunday, 11 a.m. ET)
Reasons to watch: If last weekend’s game between City and Arsenal was a clash between two sides that could potentially be fighting for the title in May, this match is the real deal. The game brings together two of the most feared strikers in world football: City forward Sergio Aguero and the Blues’ Diego Costa, who has made a sensational start to life in the Premier League. Chelsea top the table with a perfect record from their four games, City are the defending champions. Need we say more?
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AC Milan take on Juventus at San Siro (live, Saturday, 2:45 p.m. ET)
Reasons to watch: This match is special for all sorts of reasons. Firstly, Juventus coach Massimiliano Allegri returns to AC Milan for the first time since he was fired by the club in January. Allegri won the title with the Rossoneri in his first season in charge so what sort of a reception will he receive from the AC Milan fans? And his AC Milan counterpart, Filippo Inzaghi, was a prolific striker for the Old Lady, scoring 57 goals in 120 appearances between 1997-2001. Juventus are the champions and neither side has dropped points from their first two games. It's safe to expect fireworks on Sunday.
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Manchester United show travels to Leicester City (live, Sunday, 8:30 a.m. ET)
Reasons to watch: Many had written off the Louis van Gaal revolution after a poor start which yielded just two points from United’s first three games against teams they were expected to beat comfortably. But that stuttering beginning became just a memory following a crushing 4-0 win against QPR. No-one had a clue about LVG’s starting lineup for that game and with Radamel Falcao increasing his fitness and Robin van Persie looking less than sharp, is this time for the Colombian to start? Leicester have made a good start to the season and will be no pushovers.
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Alan Pardew’s tenure is on the line as Newcastle host Hull (live, Saturday, 10 a.m. ET)
Reasons to watch: Magpies fans are planning a pre-match demonstration to protest against the reign of Pardew. Newcastle made some decent signings in the summer but surprisingly they have failed to win any of their first four games and are bottom of the table. If the performances had been positive, Pardew could sleep easily but last weekend’s rout by Southampton was embarrassing. Defeat to an ambitious Hull side could spell the end for Pardew.
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Arsenal look to bounce back against Paul Lamber's Aston Villa (live, Saturday, 10:00a.m. ET)
Reasons to watch: Not many people would have predicted Aston Villa to be sitting in second place in the Premier League table after four games, but Lambert and his assistant Roy Keane, who enjoyed a few rumbles with Arsenal during his time at Manchester United, have got the Midlanders firing. Arsenal, who were torn apart by Borussia Dortmund in the Champions League midweek, are also unbeaten but Arsene Wenger has spent the last couple of days defending the form of his record signing Mesut Ozil. Can the Gunners bounce back from that crushing defeat in Germany?
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Queretaro's Ronaldinho hopes to make-up for disastrous debut vs. Chivas (live, Sunday, 6 p.m. ET)
Reasons to watch: The Brazilian superstar did not start his Mexico career on the right foot after blasting a penalty kick to the nosebleeds in Queretaro's 1-0 defeat to Tigres in Copa MX. Though White Roosters manager Ignacio Ambríz has not assured 'Dinho' will start on Sunday, the former Barcelona and PSG standout will hope to make amends as his side travels to Guadalajara to face Chivas in a crucial Liga MX clash.
Reasons to watch: Playoff implications are on the line as the winner of the Cascadia clash will sole possession for the fifth and final playoff spot in the Western Conference. If the Aug. 30 match is any indication, Vancouver will need to a better defensive approach to avoid another collapse, which is a tall task given the home-field advantage Portland will have at Providence Park.
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Can Paris St. Germain stop its early-season struggles against Olympique Lyon? (live, Sunday, 3 p.m. ET)
Reasons to watch: The defending Ligue 1 champs have had a slow start to their league campaign, settling for draws against Reims, Evian and Rennes, respectively (not to mention their midweek Champions League stalemate to Ajax). With Zlatan Ibrahimovic and Edinson Cavani eager to end PSG's malaise, Lyon will not make it easy for the Parisians on Sunday night.
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Real Madrid open La Liga Saturday with test at Deportivo La Coruña (live, Saturday, 10 p.m. ET)
Reasons to watch: Real Madrid boss Carlo Ancelotti admits he is puzzled by the furore surrounding his side's indifferent start to the season -- pointing out they are barely a month into the campaign. Though Sociedad and Atletico are no slouches, expectations are always high at the Bernabeu and rightfully so. If Cristiano Ronaldo and Co. manage to squash newly-promoted Deportivo in a convincing fashion, expect critics to settle down for a week (Source: Sky Sports).
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Barcelona hope to maintain perfect record at Levante (live, Sunday, 3 p.m. ET)
Reasons to watch: At the start of the seasons, pundits were quick to point at Barcelona's backline as its weakest link. Fast forward a month into the season as Barca are the only team with a 100 percent record in La Liga and have yet to concede a goal, and Luis Enrique's new-look side will be expected to continue their winning streak when they go to rock-bottom Levante (Source: Sky Sports).