Liverpool and Everton clash in Merseyside derby at Anfield (live, Saturday, 7:45 a.m. ET)
Reasons to watch: Saturday’s lunchtime kickoff sees one of the world’s friendlier rivalries take place at Anfield -- and there’s plenty at stake. The Reds finished runners-up to Manchester City last season, while the Blues secured a Europa League spot by claiming fifth spot. However, neither team is inside the top half of the table after five games. Brendan Rodgers’ men must bounce back from two consecutive Premier League defeats, while the Toffees need to recover from a shock home defeat by Crystal Palace. Oh, and Everton have not won at Anfield in the Premier League for 15 years. Bring it on.
Arsenal face north London rivals Tottenham in Saturday's showpiece (live, Saturday, 12:30 p.m. ET)
Reasons to watch: Saturday’s action concludes with an absolute cracker in which goals are usually guaranteed. Although the Gunners beat Spurs 1-0 last season, the previous five encounters between the sides at Emirates reads like this: 5-2, 5-2, 2-3, 3-0, 4-4. Arsenal, one of two clubs still unbeaten in the Premier League, bounced back from their defeat at Borussia Dortmund with a stunning win at Aston Villa. Spurs have picked up just one point from their last three games. Unlike Liverpool and Everton, these two sets of supporters really hate each other, meaning something has to give on Saturday.
AFP/Getty ImagesCARL COURT
Manchester United meet buoyant West Ham at Old Trafford (live, Saturday, 10 a.m. ET)
Reasons to watch: Anyone expressing confidence about the team Manchester United boss Louis van Gaal will field or the sort of performance they will deliver needs to be taken away and admitted to the nearest hospital. Everyone thought United were back in business when they crushed QPR 4-0, but they reckoned without one of the most remarkable comebacks on the following weekend when Leicester twice came back from two goals down to sink the Red Devils 5-3. West Ham are fresh from beating Liverpool 3-1, so this won’t be a cakewalk.
Man Utd via Getty ImagesMatthew Peters
Barcelona hope to remain La Liga leaders after battle vs. Granada (live, Saturday, 12 p.m. ET)
Reasons to watch: Barcelona may be sitting atop La Liga, but there were rumblings of discontent from supporters on Wednesday night when Luis Enrique’s men failed to register a single shot on target at Malaga. The 0-0 draw ended Barca’s perfect start to the season and they face a side that was also unbeaten until a 1-0 home defeat by Levante. Neymar was passed fit to face the Andalucians, but was taken off midway through the second half. Will he start against Granada?
AFP/Getty ImagesJORGE GUERRERO
Sevilla could be top of the table as they visit La Liga champions Atletico (live, Saturday, 2 p.m. ET)
Reasons to watch: The last, and only, time Sevilla won La Liga, World War II had finished the year before. No one is talking about the title this year, but Sevilla could -- and it’s a long shot -- be top of the tree on Saturday evening if they manage to beat the defending champions and Barca slip up at home to Granada, and Valencia drop points against Sociedad. Atletico are also in good form, and both sides go into the match unbeaten. Could be a classic.
AFP/Getty ImagesCRISTINA QUICLER
Villarreal welcome Real Madrid to town at the Madrigal (live, Saturday, 10 a.m. ET)
Reasons to watch: An entertaining match for soccer fans as La Liga gets Saturday started with a delightful treat. After suffering successive defeats to Atletico and Real Sociedad in La Liga, Real have bounced back with authority, collecting victories over Basel (in Champions League) Deportivo and Elche, respectively. Carlo Ancelotti's men have scored 13 goals in the process and take their high-flying exploits versus a Yellow Submarine side that are always a tough bunch to crack at the Madrigal.
Getty ImagesManuel Queimadelos Alonso
The Revierderby takes center stage as Schalke, Borussia Dortmund resume their hostilities (live, Saturday, 9:30 a.m. ET)
Reasons to watch: The 145th edition of the local derby between Schalke and Dortmund takes place with a whole region standing still for one of the most important 90 minutes of the season. The fact only two points separate the two sides, who have both made indifferent starts to the season, only raises the stakes with neither able to afford defeat ahead of their Champions League obligations next week (Source: Sky Sports).
Bongarts/Getty ImagesJuergen Schwarz
Surprise package Atlas aim to keep pace in Liga MX at Monterrey (live, Saturday, 8 p.m. ET)
Reasons to watch: Guadalajara's other club sit second place in Mexico's top-flight and can surprisingly leapfrog into first with a victory over Monterrey and a Club America loss. Under Tomás Boy's tutelage this season, Los Zorros travel to Estadio Tecnológico against a side looking to bouncing back from a heartbreaking defeat to Cruz Azul last week.
LatinContent/Getty ImagesRefugio Ruiz/STR
Paris Saint-Germain travel to Toulouse looking to regain traction in Ligue 1 (live, Saturday, 11 a.m. ET)
Reasons to watch: The defending French champs have had a slow start to its season and currently occupy fourth place in France's top flight. With a Champions League date with Barcelona next week, Edinson Cavani and Co. could leapfrog to second place in Ligue 1 with a victory over mid-table side Toulouse at Stade Municipal this weekend.
Getty ImagesJean Catuffe
MLS glamor clubs meet as LA Galaxy host NY Red Bulls (live, Sunday, 8:30 p.m. ET)
Reasons to watch: Two of Major League Soccer's marquee franchises meet with plenty at stake to say the least. The Galaxy hope to extend its unbeaten streak to nine games, while also aiming to keep chase for the Supporters' Shield. Meanwhile, the Red Bulls cannot afford to let points slip as they've yet to lock up a playoff spot in the Eastern Conference. Expect fireworks in Carson, Calif. this weekend (Source: Kyle McCarthy / Inside MLS Blog).