Simpson, the second-year Minnesota Vikings receiver, has been arrested on suspicion of driving while intoxicated.
Simpson, 27, was being held Saturday without bail at the Hennepin County jail, according to its website. He was arrested by the Minnesota State Patrol and booked at 5:39 a.m. local time.
According to Minnesota state police public information officer Lt. Eric Roeske, a state trooper responded at 4:03 a.m. to a stalled car which was blocking lanes on I-394 near downtown Minneapolis. When the officer arrived, Simpson exited the car and the officer "observed signs of intoxication (watery eyes, slightly slurred speech)" and also "detected (a) strong odor of alcoholic beverages on Simpson."
Simpson said he was coming from the Pourhouse, a bar located on 5th Street in downtown Minneapolis. He denied drinking but failed field sobriety tests and was arrested. Simpson, who was alone in his car, did not provide any resistance.
Taken to the Hennepin County jail, Simpson refused to take a breath test and was booked for a DWI/refusal to take breath test.
Currently playing in Minnesota on a one-year contract, Simpson leads the Vikings with 491 yards receiving and is on pace for a career high in receptions. He currently has 33 receptions for 491 yards and a 14.9 yards-per-catch average.
The athletic receiver spent his first three NFL seasons in Cincinnati, where he was initially taken in the second round of the 2008 NFL Draft out of Coastal Carolina. During his time in Cincinnati Simpson once spent 15 days in jail for a felony drug conviction tied to a marijuana shipment to his home. That earned the receiver a three-game suspension from the NFL in 2012.
An NFL spokesperson said the league will review the matter.
The Vikings said in a press release that they "are aware of the matter involving Jerome Simpson. We are continuing to gather information and will have further comment at the appropriate time."
Minnesota beat Washington, 34-27, on Thursday, so players had the weekend off.
FOX Sports North's Brian Hall contributed to this story.