Two stars missing Colts-Texans opener
Texans running back Arian Foster was also inactive after sitting out practice all week to nurse a left hamstring injury. Foster, the NFL's leading rusher in 2010, rushed for 231 yards in a season-opening victory over the Colts last year.
The four-time MVP did not travel with the team after undergoing more surgery Thursday. Kerry Collins, signed on Aug. 24, will start in Manning's place.