Jones-Drew misses 4th straight game for Jaguars
Jones-Drew will miss his fourth straight game with a sprained left foot. Lowery (ankle) will miss his fifth straight game and Mathis (groin) will sit out for the fourth straight game.
Backup running back Ben Tate (hamstring) and nose tackle Shaun Cody (back) are among the inactive players for Houston. Cornerbacks Roc Carmichael and Brandon Harris, tackle Andrew Gardner and guards Cody White and Brandon Brooks are also inactive.
Houston activated linebacker Darryl Sharpton from the physically unable to perform list and cut safety Troy Nolan.