Star receiver Andre Johnson and safety Danieal Manning are among the inactive players for Houston in Sunday's game against Jacksonville.
Johnson will sit out his fourth straight game as he continues to nurse a right hamstring injury. Manning is out a minimum of four weeks after breaking his left leg in last week's 41-7 win at Tennessee.
Jacoby Jones will start for Johnson, and Troy Nolan will take Manning's spot for the Texans.
Left guard Eben Britton (back) and backup safety Courtney Greene (hamstring) are among the inactive players for the Jaguars. Will Rackley will start in Britton's place.