The Titans' offense kept rolling in Thursday night's win over the Jaguars, while Blake Bortles simply kept regressing.
Here are the 10 best things to look for when Week 8 continues on Sunday, including Tom Brady's shot at revenge in Buffalo against Rex Ryan's Bills.
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Best chance for an upset
Seahawks-Saints: The 2-4 Saints should have a nice chance at home against a Seattle team that's coming in at less than 100 percent.
The Seahawks feature one of the league's top defenses, but will be without both Michael Bennett and Kam Chancellor. Drew Brees (3) and New Orleans have put up a ton of points just about every week, and a hobbled Russell Wilson could have trouble keeping pace.
Getty ImagesGrant Halverson
Best survivor pool pick
Jets-Browns: The sight of Ryan Fitzpatrick on the road doesn't exactly inspire confidence, but with six teams on bye along with the fact that there are few (if any) obvious choices, betting on the Browns to remain winless seems like one of the safest Week 8 options.
"Detroit has the worst defense in the league by DVOA; Houston has the worst offense. The Lions can't run the ball; the Texans can't stop opposing rushers. Matthew Stafford has been solid this year; Houston's strength is its pass defense."
Best bad game
Cardinals-Panthers: The rematch of last year's NFC Championship Game isn't at all what we were expecting with both teams struggling to this point in the season.
But despite Arizona's 3-3 record and Carolina's 1-5 start, both teams are just two games in the loss column back of the leaders in their respective divisions, with plenty of football left to be played — which should make for a fairly competitive contest.
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Best fantasy option
Jacquizz Rodgers is still available in plenty of leagues, yet he's set to be Tampa Bay's primary running back for a third straight week. And, he'll be facing a Raiders team that ranks just 28th in rushing defense.
Best chance for a shootout
Packers-Falcons: We know Julio Jones (11) and Atlanta's high-powered offense will have no trouble putting points on the board at home against a depleted Green Bay secondary. And with no healthy options at running back, Aaron Rodgers will have to try to keep up all by himself.
The oddsmakers set the over/under for this one at 53.5, and as long as you believe Green Bay can hang for a while, the over seems like a pretty safe bet.
Getty ImagesScott Cunningham
Best bet against the spread
Patriots over Bills: New England is a 6.5-point favorite in Buffalo on Sunday, and beating the Bills at home will be no small task.
But Bill Belichick and the Patriots are all about revenge, and after Buffalo crushed New England at home in the final week before Tom Brady's return, you can expect an exceptional level of focus from Brady & Co. that'll lead to a two-score win.
Chargers-Broncos: The last time these teams met, Philip Rivers used an efficient passing attack to engineer a 21-13 home win.
San Diego's defense has been playing well ever since, thanks to rookie defensive end Joey Bosa (99) finally hitting his stride. We hear Denver's defense is pretty good, too, so expect another low-scoring battle in this AFC West matchup.
FOX Sports San DiegoKevin Carden
Best late game
Eagles-Cowboys: A battle of rookie quarterbacks Carson Wentz and Dak Prescott is also a key NFC East game between the 4-2 Eagles and the 5-1 Cowboys.
The Eagles are third in the league in points allowed (14.7), but are just middle of the pack against the run — which just happens to be the specialty of a Dallas offense that features Ezekiel Elliott.
Philadelphia may need to force some turnovers while hoping Wentz can return to his early-season form in order to have a shot in this one.
Patriots-Bills: New England heads to Buffalo looking to avenge a 16-0 loss to the Bills at home in Week 4, just before Tom Brady returned.
The Patriots have won by an average of more than 16 points in the three games with Brady under center this season, and you know they'll be fired up to try to keep Rex Ryan's mouth shut.