It's the ninth straight game Wade has missed while working his way back from a hamstring injury. Heat coach Erik Spoelstra said after the team's morning shootaround the All-Star guard will not play. Wade last played March 26, also against the Pacers.
The Miami-Indiana winner will have first place in the Eastern Conference, and be on pace for home-court advantage for at least the first three rounds of the playoffs.
Miami enters Friday 36-15 when Wade plays, 18-10 when he does not.