With the spotlight on Bryant during the final game of his career in his hometown, the Sixers stole the show and defeated the Los Angeles Lakers 103-91 on Tuesday night for their first victory of the season.
The Sixers remain tied for the worst start in NBA history with the 2009-10 New Jersey Nets, who also opened 0-18.
It was the first win for the Sixers since March 25 at Denver.
"Finally," forward Nerlens Noel said.
Coach Brett Brown’s team has long languished at the bottom of the NBA standings and reeled off two separate losing streaks of at least 26 games in his three seasons.
For one night, in front of a sellout crowd of 20,510 that came to cheer Bryant, the streaks hardly mattered.
"I’m pleased for the city," Brown said. "We don’t want this streak continuing."
Hours earlier, Bryant felt the love in Philadelphia as soon as he entered the arena.
He took selfies with fans who might never see him play again, and his presence injected a playoff atmosphere into a city that has lost much of its passion in NBA basketball.
With a packed crowd standing and roaring in appreciation, Bryant was lauded like a hometown hero, not the "Hometown Zero" he was once labeled in Philadelphia’s tabloids.
Bryant, who will end his 20-year career this season, opened the first leg of his farewell tour in his hometown and was feted with the kind of reverence and gratitude normally reserved for a Sixers great.
"I wasn’t expecting that type of reaction, ovation," he said. "Deeply appreciative beyond belief. It was really, really special."
Playing with the shot selection of a pickup artist, Bryant tried to deliver a special performance in his finale.
He buried a step-back 3-pointer off the opening tip.
He hit another 3 on the next possession.
Bryant made it 3 for 3 and had the Philly crowd chanting "M-V-P!" as he turned back the clock to his championship form.
"It was a little spurt of old-school Kobe," Noel said.
Bryant said he could tell the start made the Sixers a little starstruck — most were babies when he started his career.
"I could sense they were like `I really don’t want to touch him.’ … `Is this going to be an 81 type of situation?’" Bryant said. "I’m just playing possum because I know my legs ain’t going to carry this energy for 48 minutes."
Bryant scored 20 points on 7-of-26 shooting and made four 3s.
By the fourth quarter, the Philly fans had turned their attention toward the home team, chanting "Beat L.A.!" when beleaguered rookie Jahlil Okafor made a layup for a 94-80 lead.
Okafor, the No. 3 overall pick out of Duke, has been attached to a string of off-court incidents that included reckless driving and a fight in Boston. Brown said Okafor, who has apologized for his recent decisions, will likely soon be accompanied by team security on public outings.
Bryant said he would simply tell the 19-year-old rookie to stay focused on basketball.
The Sixers stayed focused and finally finished the job after taking an 80-75 lead into the fourth.
The 76ers had led after three quarters three other times this season: Nov. 21 at Miami (led 74-67, lost 96-91), Nov. 25 at Boston (led 62-57, lost 84-80) and Nov. 29 at Memphis (led 67-64, lost 92-84), according to STATS.
Robert Covington scored 23 points and Jerami Grant and Noel had 14 for the Sixers.
The win belonged to Philadelphia. The night belonged to Bryant.
His homecoming game came with a rare emotional tug for the player fans loved to boo through the years. He waved to the crowd and bowed his head in appreciation as "Kobe!’ chants filled Wells Fargo Center.
He was greeted at midcourt by his Lower Merion high school coach, Gregg Downer, and 76ers great Julius Erving. Bryant hugged both in front of a crowd filled with purple-and-gold No. 24 jerseys.
He smiled after every shot and bantered with fans, some who made "Thank you, Kobe" signs.
In a reference to the sorry state of the entire Philly sports scene, one fan held a sign that read "Why Can’t Chip Kelly Retire Instead."
Bryant even smirked in the third quarter when a brief scuffle broke out among Lakers center Roy Hibbert, who appeared to push a referee, and Philadelphia’s Isaiah Canaan and JaKarr Sampson. All three were hit with technical fouls.
Bryant thumped his chest, waved to the fans, blew a kiss and was serenaded with "Kobe!" chants as he walked off Philadelphia’s court for the final time.
"You can’t script this stuff — I can’t," he said. "The amount of respect and appreciation and adoration I have for the city and to be able to have this moment here just means everything to me."
Lakers: Los Angeles is 2-15 and has the worst record in the Western Conference. … The Lakers opened an eight-game road trip.
Sixers: Moses Malone, the late 76ers star selected one of the NBA’s 50 greatest players, was honored at halftime. Malone, who died in September at 60, was the NBA Finals MVP in 1983 when he led the Sixers to the title. His No. 2 was on the back of Philadelphia’s warmup jerseys with "Chairman of the Boards" on the front. The Sixers will retire his number next season.
Grant had four blocked shots, Noel had nine rebounds, T.J. McConnell had six assists.
Lakers: At the Washington Wizards on Wednesday night.
Sixers: At the New York Knicks on Wednesday night.