MAY 27, 2014 12:13a ET
The defending World Series champions trailed 6-1 after the fourth inning of the interleague matchup, with starter Clay Buchholz walking a career-high eight in only three-plus innings.
But Ortiz tied it by hitting a three-run homer off Ervin Santana in the fifth. With Red Sox fans at Turner Field chanting ''Papi! Papi!'' the World Series MVP then gave Boston the lead with a bases-loaded sacrifice fly off Ian Thomas (1-2) in the seventh.
Following pregame declarations of confidence from manager John Farrell and general manager Ben Cherington, the Red Sox came back to end their worst skid since an 11-game slide in 1994.
LOS ANGELES (AP) - Hyun-Jin Ryu took a perfect game into the eighth inning - one day after teammate Josh Beckett threw a no-hitter - and Los Angeles held on to beat Cincinnati.
The left-hander from South Korea came close to making the Dodgers the first team in major league history with consecutive no-hitters. Beckett won 6-0 in Philadelphia on Sunday.
Cincinnati scored three times in the eighth, but right fielder Yasiel Puig made a key defensive play when he cut off Billy Hamilton's two-run double in the gap. The relay home held Skip Schumaker at third, and Kenley Jansen struck out Brandon Phillips with the bases loaded to preserve a 4-3 lead.
Jansen also worked the ninth, retiring Devin Mesoraco with two on for his 15th save.
Ryu (5-2) was charged with three runs and three hits in 7 1-3 innings, improving to 6-0 in six starts against the Reds. He struck out seven and walked none while winning for the first time at Dodger Stadium this season.
Johnny Cueto (4-4) allowed four hits and four runs - one earned - in 6 1-3 innings.
Pinch-hitter Alfonso Soriano and Brendan Ryan each added an RBI for the Yankees, who took the opener of a three-game interleague series for their third straight win. Alfredo Aceves (1-2) worked two scoreless innings and David Robertson earned his 11th save in 12 chances.
A standing-room crowd of 47,311, the third-largest at 9-year-old Busch Stadium, showed up to see an opponent making only its second appearance in St. Louis since losing to the Cardinals in the 1964 World Series.
Cardinals pitchers retired 20 of 21 batters before the 12th, when Randy Choate (0-2) faced five batters and four reached safely.
SAN FRANCISCO (AP) - Jeff Samardzija struck out a season-high 10 for his first win since last August, snapping a 16-start winless streak for Chicago.
Samardzija (1-4) allowed six hits and walked none in seven-plus innings. He also had an RBI double during a three-run fourth.
The right-hander entered with six no-decisions in his first 10 outings this year despite leading the majors with a 1.46 ERA.
The Mets announced after the game that they had fired hitting coach Dave Hudgens. They also cut reliever Jose Valverde, who gave up Sanchez's go-ahead hit.
Sanchez upped his average against the Mets to .324 and has 34 RBIs against New York, his best totals against any NL team. He homered off Scott Rice while hitting for Ike Davis, who was making his return to Citi Field after being traded to the Pirates in mid-April.
Valverde (1-1) was booed off the field after allowing pinch-hitter Jose Tabata's tying single in the eighth. Valverde returned for the ninth and was even worse.
Tony Watson (5-0) pitched an inning for the win. Mark Melancon got his 10th save.
Stanton doubled and scored in the first inning, then launched a long two-run homer in the third.
Stanton is hitting .333 (43 for 129) with 14 home runs and 27 RBIs in Washington since his career began in 2010. He has homered at Nationals Park more than any other visiting player during that time.
The Marlins improved to 7-17 on the road; they're 20-8 at home.
Nathan Eovaldi (4-2) pitched 6 1-3 innings, giving up two runs and three hits. Steve Cishek worked the ninth for his 11th save.
Adam LaRoche homered for the Nationals, who had won 12 of their last 13 against Miami at home. Tanner Roark (3-3) went seven innings.
A day after Dodgers right-hander Josh Beckett threw a no-hitter against the Phillies, leadoff man Ben Revere started with a single for the first of Philadelphia's 12 hits.
Kendrick (1-5) allowed six hits over 6 2-3 innings to earn his first win since last Aug. 6, a span of 16 winless starts. His best performance in a while came against the top offense in the majors. The Rockies are first in runs (262) and batting average (.291).
Jhoulys Chacin (0-4) gave up four runs and seven hits in five-plus innings. He has lost five straight decisions dating to last season.
MILWAUKEE (AP) - Jonathan Schoop hit two home runs and newly acquired Nick Hundley singled in the go-ahead run in the 10th inning to lift Baltimore to victory in the interleague contest.
Down 6-4 with two outs in the ninth, the Orioles rallied off Milwaukee closer Francisco Rodriguez. Schoop's second homer cut it to one. After pinch-hitter Delmon Young singled, Nick Markakis hit a game-tying double.
With two outs in the 10th, J.J. Hardy doubled off Rob Wooten (1-2) and scored on Hundley's single.
Darren O'Day (2-0) pitched a scoreless inning of relief to get the win. Zach Britton pitched out of trouble in the 10th, to record his third save in three opportunities.
PHOENIX (AP) - A.J. Pollock hit a two-run homer on the first pitch he saw with two outs in the ninth inning to give Arizona a victory over San Diego.
Brad Ziegler (1-1) pitched two scoreless innings for the win.